GLPBio

MAGL

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Monoacylglycerol lipase (MGL) is a 33 kDa serine hydrolase that catalyses the hydrolysis of monoacylglycerols to their corresponding fatty acids. The enzyme is found both in the brain and in peripheral tissues such as the kidney, ovary, testis, adrenal gland, adipose tissue and heart. The three-dimensional structure of MGL has been elucidated by X-ray crystallography, and the enzyme has been shown to be a dimeric molecule with amphitropic properties, that is, it can exist both in a soluble form and associated with the membrane lipid bilayers. Mutagenesis studies have demonstrated the importance of the catalytic triad of ser122, asp239 and his269 that the enzyme shares with other enzymes in the α/β hydrolase superfamily. The substrate is recruited via a wide hydrophobic tunnel, where it can then interact with the catalytic triad at the end of the tunnel.

MGL inhibitors have lagged behind, but have a potential advantage over FAAH inhibitors in terms of eCB specificity of action given that the N-acylethanolamines are a class of compounds with multiple biological actions.

Products Related to MAGL(19)

  • GC10162 structure
    GC10162JJKK 048
    CAS: 1515855-97-6
    Purity: >98.00%

    monoacylglycerol lipase (MAGL) inhibitor

  • GC12693 structure
    GC12693JZL 195
    CAS: 1210004-12-8
    Purity: >98.00%

    JZL 195 is a highly selective and irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), with IC 50 values of 2nM and 4nM, respectively.

  • GC13763 structure
    GC13763KT203
    CAS: 1402612-64-9
    Purity: >99.00%

    ABHD6 inhibitor

  • GC14079 structure
    GC14079MJN110
    CAS: 1438416-21-7
    Purity: >99.50%

    MAGL inhibitor

  • GC14390 structure
    GC14390JZL184
    CAS: 1101854-58-3
    Purity: >98.00%

    JZL184 is a potent, selective and irreversible inhibitor of monoacylglycerol lipase (MAGL), which blocks the hydrolysis of 2-arachidonoylglycerol (2-AG) in the brain membrane with an IC 50 value of 8nM.

  • GC15074 structure
    GC15074WWL 70
    CAS: 947669-91-2
    Purity: >98.00%

    WWL 70 is a selective alpha/beta hydrolase domain 6 (ABHD6) inhibitor with an IC 50 of 70nM.

  • GC16756 structure
    GC16756KT182
    CAS: 1402612-62-7
    Purity: >98.00%

    ABHD6 (a/b-Hydrolase Domain Containing 6) inhibitor

  • GC17304 structure
    GC17304JW 642
    CAS: 1416133-89-5
    Purity: >98%

    monoacylglycerol lipase (MAGL) inhibitor

  • GC17385 structure
    GC17385KML 29
    CAS: 1380424-42-9
    Purity: >98.50%

    KML 29 is reported to display IC50 values of 43, 15, and 5.9 nM toward rat, mouse, and human monoacylglycerol lipase (MAGL), respectively.

  • GC17855 structure
    GC17855SA 57
    CAS: 1346169-63-8
    Purity: >98%

    FAAH inhibitor

  • GC19412 structure
    GC19412ABX-1431
    CAS: 1446817-84-0
    Purity: >99.50%

    ABX-1431 is a highly potent, selective, and orally available, CNS-penetrant monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 14 nM.

  • GC34640 structure
    GC34640JZP-430
    CAS: 1672691-74-5
    Purity: >99.50%

    JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

  • GC36401 structure
    GC36401KT185
    CAS: 1472640-86-0
    Purity: >99.00%

    KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells.

  • GC38135 structure
    GC38135MJN110
    CAS: 1438416-21-7
    Purity: >98%

    A selective MAGL inhibitor

  • GC38638 structure
    GC38638Euphol
    CAS: 514-47-6
    Purity: >98.00%

    Euphol, a major constituent found in Euphorbia tirucalli effectively inhibited via a reversible mechanism, the monoacylglycerol lipase (MGL) activity (IC50 = 315 nM), which is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).

  • GC62821 structure
    GC62821AA38-3
    CAS: 65815-76-1
    Purity: >99.50%

    AA38-3 is a serine hydrolase (SH) inhibitor.

  • GC63055 structure
    GC63055MAGL-IN-4
    CAS: 2135785-20-3
    Purity: >98%

    MAGL-IN-4 is an orally active, selective and reversible monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 6.2 nM.

  • GC70327 structure
    GC70327PF-06795071
    CAS: 2075629-81-9
    Purity: >99.00%

    PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM.

  • GC70430 structure
    GC70430Dimepiperate
    CAS: 61432-55-1

    Dimepiperate (MY 93) is a thiocarbamate (TC) pesticide.