Melatonin Receptors
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Melatonin Receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 and MT2 receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 has been identified in amphibia and birds. The MT1 subtype's expression in the pars tuberalis of the pituitary gland and suprachiamatic nuclei of the hypothalamus is indicative of melatonin's circadian and reproductive functional involvement. The MT2 subtype's expression in the retina is suggestive of melatonin's effect on the mammalian retina occurring through this receptor. Research suggests that melatonin acts to inhibit the Ca2+-dependent release of dopamine. Melatonin's action in the retina is believed to affect several light-dependent functions, including phagocytosis and photopigment disc shedding.
Products Related to Melatonin Receptors(23)
- GC112882-PhenylmelatoninCAS: 151889-03-1Purity: >98%
2-Phenylmelatonin is a high affinity melatonin (MT) membrane receptor agonist.
- GC15365N-AcetylserotoninCAS: 1210-83-9Purity: >98.00%
N-Acetylserotonin, a chemical intermediate in melatonin biosynthesis, activates tyrosine kinase receptor B (TrkB) in a circadian rhythm manner.
- GC17981AgomelatineCAS: 138112-76-2Purity: >98.50%
Agomelatine is a melatonin (MT) receptor agonist with K i values of 0.1 nM and 0.12 nM for MT1 and MT2, respectively. Agomelatine is also a 5-hydroxytryptamine (5-HT) receptor antagonist with K i values of 631 nM and 660 nM for 5-HT2C and 5-HT2B respectively.
- GC30781Tasimelteon (BMS-214778)CAS: 609799-22-6Purity: >99.00%
Tasimelteon (BMS-214778) (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA).
- GC35269Agomelatine hydrochlorideCAS: 1176316-99-6Purity: >99.50%
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively.
- GC35270Agomelatine L(+)-Tartaric acidCAS: 824393-18-2Purity: >99.50%
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively.
- GC37070Ramelteon metabolite M-IICAS: 896736-21-3Purity: >98%
A mixed isomer preparation of ramelteon metabolite M-II
- GC60241Melatonin D5CAS: 66521-38-8Purity: >98%
An internal standard for the quantification of melatonin
- GC62825ACH-000143CAS: 2225836-30-4Purity: >98.50%
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.
- GC69448Melatonin-d3CAS: 90735-69-6Purity: >99.50%
Melatonin-d3 is the deuterated form of melatonin. Melatonin is a hormone produced by the pineal gland that activates melatonin receptors. It plays a role in sleep and has important antioxidant and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor that induces apoptosis in human liver cancer cells through COX-2 downregulation. Melatonin also reduces palmitic acid-induced mouse granule cell apoptosis by attenuating endoplasmic reticulum stress.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC11188 | GR 135531 | 190277-13-5 | >98% | |
MT3 receptor agonist | ||||
| GC11288 | 2-Phenylmelatonin | 151889-03-1 | >98% | |
2-Phenylmelatonin is a high affinity melatonin (MT) membrane receptor agonist. | ||||
| GC12014 | 6-Chloromelatonin | 63762-74-3 | >98% | |
melatonin agonist | ||||
| GC13047 | N-Acetyltryptamine | 1016-47-3 | >98% | |
melatonin receptor modulator | ||||
| GC14690 | 2-Iodomelatonin | 93515-00-5 | >99.00% | |
melatonin agonist | ||||
| GC14728 | DH 97 | 220339-00-4 | >98% | |
MT2 melatonin receptor antagonist | ||||
| GC15053 | Ramelteon | 196597-26-9 | >99.50% | |
Agonist of melatonin receptor(M1-M2),highly selective | ||||
| GC15365 | N-Acetylserotonin | 1210-83-9 | >98.00% | |
N-Acetylserotonin, a chemical intermediate in melatonin biosynthesis, activates tyrosine kinase receptor B (TrkB) in a circadian rhythm manner. | ||||
| GC15618 | Melatonin | 73-31-4 | >98.50% | |
Melatonin receptors agonist | ||||
| GC16020 | 8-M-PDOT | 134865-70-6 | >98.00% | |
Melatonin receptor agonist | ||||
| GC16186 | 4-P-PDOT | 134865-74-0 | >98.00% | |
4-P-PDOT is an orally active, highly selective melatonin MT2 receptor antagonist. 4-P-PDOT selectivity for the MT2 receptor is over 300 times greater than for MT1 (Ki values of 0.46nM and 56nM, respectively). | ||||
| GC17898 | Luzindole | 117946-91-5 | >98.00% | |
Luzindole is a selective melatonin receptor (MT) antagonist, with a Ki value of 158nM for MT1 and 10.2nM for MT2. | ||||
| GC17981 | Agomelatine | 138112-76-2 | >98.50% | |
Agomelatine is a melatonin (MT) receptor agonist with K i values of 0.1 nM and 0.12 nM for MT1 and MT2, respectively. Agomelatine is also a 5-hydroxytryptamine (5-HT) receptor antagonist with K i values of 631 nM and 660 nM for 5-HT2C and 5-HT2B respectively. | ||||
| GC30781 | Tasimelteon (BMS-214778) | 609799-22-6 | >99.00% | |
Tasimelteon (BMS-214778) (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). | ||||
| GC35269 | Agomelatine hydrochloride | 1176316-99-6 | >99.50% | |
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. | ||||
| GC35270 | Agomelatine L(+)-Tartaric acid | 824393-18-2 | >99.50% | |
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. | ||||
| GC37070 | Ramelteon metabolite M-II | 896736-21-3 | >98% | |
A mixed isomer preparation of ramelteon metabolite M-II | ||||
| GC38844 | S26131 | 296280-56-3 | >99.50% | |
S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. | ||||
| GC60241 | Melatonin D5 | 66521-38-8 | >98% | |
An internal standard for the quantification of melatonin | ||||
| GC62825 | ACH-000143 | 2225836-30-4 | >98.50% | |
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively. | ||||
| GC64204 | S-22153 | 180304-07-8 | >98% | |
S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. | ||||
| GC68331 | Ramelteon metabolite M-II-d3 | 1246812-22-5 | >98% | |
| GC69448 | Melatonin-d3 | 90735-69-6 | >99.50% | |
Melatonin-d3 is the deuterated form of melatonin. Melatonin is a hormone produced by the pineal gland that activates melatonin receptors. It plays a role in sleep and has important antioxidant and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor that induces apoptosis in human liver cancer cells through COX-2 downregulation. Melatonin also reduces palmitic acid-induced mouse granule cell apoptosis by attenuating endoplasmic reticulum stress. | ||||