ACH-000143 |
| Catalog No.GC62825 |
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2225836-30-4
Sample solution is provided at 25 µL, 10mM.
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ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].ACH-000143 significantly reduces plasma glucose at 10 mg/kg (-16.4%, p < 0.05) and 30 mg/kg (-16.9%, p < 0.01)[1].
[1]. Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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