MK6-83 |
| Catalog No.GC18564 |
MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1062271-24-2
Sample solution is provided at 25 µL, 10mM.
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MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes expressing either wild type or F465L-mutated channels (EC50s = 110 and 100 nM, respectively) and in MLIV patient-derived fibroblasts. It is more effective for F465L mutations than F408Δ (EC50 = 1,230 nM). It also improves zinc trafficking out of lysosomes in F408Δ-expressing fibroblast cells.
Review for MK6-83
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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