MNK
MNK (MAP kinase-interacting kinases) is a group of serine/threonine kinase that phosphorylates eukaryotic initiation factor 4E (eIF4E) in the MAPK signaling pathways. It plays an important role in cell transformation and tumor progression.
Products Related to MNK(11)
- GC19131TomivosertibCAS: 1849590-01-7Purity: >98.00%
Tomivosertib is an orally active MNK1/2 inhibitor (IC 50 = 1–2nM).
- GC32937SLV-2436 (SEL201-88)CAS: 2095704-43-9Purity: >98.00%
SLV-2436 (SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.
- GC69013DS12881479CAS: 2373065-59-7Purity: >99.00%
DS12881479 is an effective selective Mnk1 inhibitor with an IC50 value of 21 nM. It can be used for cancer research.
- GC70832MNK1/2-IN-5CAS: 1426928-20-2Purity: >99.00%
MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.
- GC73896VNPP433-3βCAS: 1630820-51-7Purity: >98.00%
VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10666 | CGP 57380 | 522629-08-9 | >98.00% | |
MNK1 inhibitor, specific and selective | ||||
| GC19131 | Tomivosertib | 1849590-01-7 | >98.00% | |
Tomivosertib is an orally active MNK1/2 inhibitor (IC 50 = 1–2nM). | ||||
| GC32937 | SLV-2436 (SEL201-88) | 2095704-43-9 | >98.00% | |
SLV-2436 (SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively. | ||||
| GC33033 | ETC-206 | 1464151-33-4 | >99.50% | |
ETC-206 is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively. | ||||
| GC69013 | DS12881479 | 2373065-59-7 | >99.00% | |
DS12881479 is an effective selective Mnk1 inhibitor with an IC50 value of 21 nM. It can be used for cancer research. | ||||
| GC70565 | QL-X-138 | 1469988-63-3 | >99.00% | |
QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. | ||||
| GC70832 | MNK1/2-IN-5 | 1426928-20-2 | >99.00% | |
MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent. | ||||
| GC73118 | EB1 | 42951-68-8 | >99.00% | |
EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). | ||||
| GC73896 | VNPP433-3β | 1630820-51-7 | >98.00% | |
VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. | ||||
| GC79476 | ETC-501 | 3094990-88-9 | >97.00% | |
ETC-501 is a blood-brain barrier-permeable, orally active, and selective MNK1 / MNK2 inhibitor, with an IC 50 of 0.033 μM against MNK1 and 0.111 μM against MNK2. | ||||
| GC79480 | MNK-IN-5 | 97310-93-5 | >98.00% | |
MNK-IN-5 is a MNK inhibitor that suppresses MNK activity [1] . | ||||