MNS (Synonyms: 3,4Methylenedioxyβnitrostyrene, NSC 10120, NSC 105303, NSC 170724, Syk Inhibitor III) |
| Catalog No.GC10048 |
Inhibitor of Src/Syk tyrosine kinases
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1485-00-3
Sample solution is provided at 25 µL, 10mM.
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MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]
References:
[1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9.
[2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.
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