GLPBio

MRZ 2-514

Catalog No.: GC31036Purity:>98%
COASDSData Sheet
MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.

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MRZ 2-514
Cas No.: 202808-11-5
10mM (in 1mL DMSO)In Stock
$257.00
1
5mgIn Stock
$234.00
1
10mgIn Stock
$378.00
1
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Description

MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.

MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM[1].

MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid[1].

[1]. Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275

Chemical Properties

CAS No.
202808-11-5
SMILES
O=C1NNC(C2=C1C=C3C=C(Br)C=CC3=[N+]2[O-])=O
Molecular Formula
C11H6BrN3O3
Molecular Weight
308.09
Solubility
DMSO : 8.33 mg/mL (27.04 mM; ultrasonic and warming and heat to 60°C)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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