L-Biopterin (Synonyms: L-erythro-Biopterin,NSC 339699) |
| Catalog No.GC16200 |
L-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
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Cas No.: 22150-76-1
Sample solution is provided at 25 µL, 10mM.
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L-Biopterin is the oxidized form of tetrahydrobiopterin (BH4) [1].
Tetrahydrobiopterin (BH4) has been also known as sapropterin. BH4 is an essential cofactor of the three aromatic amino acid hydroxylase enzymes which has used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-HT), melatonin, norepinephrine, dopamine, epinephrine (adrenaline). BH4 is a cofactor of nitric oxide synthases [2].
L-Biopterin was reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. L-Biopterin was extremely toxic to human melanocytes in culture with the IC50 of 0.2 μM after 48 hrs. L-Biopterin was rarely existed under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo [3].
References:
[1] Schallreuter K U, Buttner G, Pittelkow M R, et al. Cytotoxicity of 6-biopterin to human melanocytes[J]. Biochemical and biophysical research communications, 1994, 204(1): 43-48.
[2] Calka J. The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons[J]. Folia Histochemica et Cytobiologica, 2006, 44(1): 3.
[3] Moore J, Wood J M, Schallreuter K U. Evidence for Specific Complex Formation between α-Melanocyte Stimulating Hormone and 6 (R)-l-Erythro-5, 6, 7, 8-tetrahydrobiopterin using Near Infrared Fourier Transform Raman Spectroscopy[J]. Biochemistry, 1999, 38(46): 15317-15324.
| Cas No. | 22150-76-1 | SDF | |
| Synonyms | L-erythro-Biopterin,NSC 339699 | ||
| Chemical Name | 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone | ||
| Canonical SMILES | NC(N=C1C2=NC([C@@H](O)[C@@H](O)C)=CN1[H])=NC2=O | ||
| Formula | C9H11N5O3 | M.Wt | 237.2 |
| Solubility | ≤1mg/ml in DMSO;0.3mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.2159 mL | 21.0793 mL | 42.1585 mL |
| 5 mM | 0.8432 mL | 4.2159 mL | 8.4317 mL |
| 10 mM | 0.4216 mL | 2.1079 mL | 4.2159 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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