Myrtillin (Synonyms: Delphinidin-3-β-D-glucoside chloride, Delphinidin-3-O-glucoside, Delphinin) |
Catalog No.GC44263
One-Click Copy Product Info
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Myrtillin (Delphinidin 3-o-glucoside) is a kind of anthocyanin monomer, which is mainly distributed in various plants and can be analyzed qualitatively and quantitatively by high performance liquid chromatography (HPLC) Mass spectrometry (Mass) and nuclear magnetic resonance (NMR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6906-38-3
Sample solution is provided at 25 µL, 10mM.
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Myrtillin is a cationic anthocyanin compound that inhibits epidermal growth factor receptor (EGFR) with an IC50 value of 2.37µM[1]. Myrtillin exhibits oxygen radical absorbance capacity (ORAC), scavenging power of ABTS (EC50=20.66µM), and DPPH-free radical (EC50=60.37µM) and inhibitory activity of α-glucosidase (IC50=239.7µM)[2]. Myrtillin combines with the bacterial protein FtsZ, NAD+-dependent DNA ligase, and amidase through hydrogen bonds and hydrophobic interactions, interfering with bacterial metabolism, inhibiting the production of ROS, and alleviating the oxidative damage caused by bacterial pathogens to Caenorhabditis elegans[3]. Myrtillin has been widely used in tumor research to inhibit the proliferation of colorectal cancer cells and leukemia cells[4].
In vitro, Myrtillin treatment for 24 hours markedly reduced the viability of HCT 116 and HT-29 cells, with IC50 values of 395.9µg/ml and 329.1µg/ml, respectively[5]. The combination treatment of 50µM Myrtillin and 1.25µg/ml lipopolysaccharide (LPS) for 24 hours induced the proliferation of mesenchymal stem cells (MSCs), promoting the increase of IL-10 and TGF-β levels and the decrease of NF-κB expression[6]. Treatment with 200µM Myrtillin for 72h suppressed MDA-MB-231 migration by disrupting actin[7].
In vivo, Myrtillin administration via intraperitoneal injection at a dose of 20mg/kg/day for 3 days reduced neuronal damage and cerebral infarction, and restored regional cerebral blood flow in a neonatal mouse model of hypoxic-ischemic encephalopathy (HIE)[8]. Oral administration of Myrtillin at a dose of 20mg/kg/day for 12 weeks alleviated aortic lesions, oxidative stress, and inflammatory responses in a high-fat diet-induced rabbit model of atherosclerosis[9].
References:
[1] Mazewski C, Liang K, de Mejia E G. Comparison of the effect of chemical composition of anthocyanin-rich plant extracts on colon cancer cell proliferation and their potential mechanism of action using in vitro, in silico, and biochemical assays[J]. Food Chemistry, 2018, 242: 378-388.
[2] Zhu C, Lü H, Du L, et al. Five blueberry anthocyanins and their antioxidant, hypoglycemic, and hypolipidemic effects in vitro[J]. Frontiers in nutrition, 2023, 10: 1172982.
[3] Nas J S B. Myrtillin prolongs lifespan and enhances tolerance against pathogenic infections in Caenorhabditis elegans[J]. Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2023, 2(3): 154-163.
[4] Iqbal S, Omara T, Kahwa I, et al. Anticancer potential of delphinidin and its derivatives: Therapeutic and mechanistic insights[J]. Medicinal Chemistry Research, 2024, 33(10): 1769-1786.
[5] Mazewski C, Kim M S, Gonzalez de Mejia E. Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico[J]. Scientific reports, 2019, 9(1): 11560.
[6] Neves B R O, de Freitas S, Borelli P, et al. Delphinidin-3-O-glucoside in vitro suppresses NF-κB and changes the secretome of mesenchymal stem cells affecting macrophage activation[J]. Nutrition, 2023, 105: 111853.
[7] Viegas O, Faria M A, Sousa J B, et al. Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption[J]. Journal of Functional Foods, 2019, 54: 393-402.
[8] Xu J, Hao P, Chen J, et al. Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization[J]. Frontiers in Pharmacology, 2026, 17: 1797078.
[9] Sun B, Li F, Zhang X, et al. Delphinidin-3-O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis[J]. Pharmaceutical biology, 2022, 60(1): 247-254.
| Cell experiment [1]: | |
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Cell lines |
MSCs |
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Preparation Method |
The cells cultured for 24 hours with 50 uM of Myrtillin and stimulated or not with 1.25 g/mL of LPS. |
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Reaction Conditions |
50 µM Myrtillin for 24 hours |
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Applications |
50 µM Myrtillin increased the percentage of cells in the S/G2/M cycle phase. Mesenchymal stem cells produce soluble factors. |
| Animal experiment [2]: | |
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Animal models |
Rabbit |
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Preparation Method |
A rabbit model of atherosclerosis (AS) was established by 12 weeks of a high-fat diet (HFD). The rabbits were divided into five groups: control, AS, simvastatin (4 mg/kg), and two Myrtillin groups (10 and 20 mg/kg). After treatment with Myrtillin or simvastatin by oral gavage for 12 weeks, the lipid profiles were measured. |
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Dosage form |
10 and 20 mg/kg Myrtillin for 12 weeks |
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Applications |
DP (20 mg/kg) decreased serum TG, TC, LDL-C, and HDL-C. Myrtillin (20 mg/kg) also reduced lipid levels in the liver and aorta. Myrtillin (20 mg/kg) down-regulated the mRNA levels of IL-6, VCAM-1, and NF-κB and up-regulated the mRNA levels of GSH-PX and SOD1. |
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References: [1]: Bruna Roberta Oliveira Neves, Sumara de Freitas, et,al. Delphinidin-3-O-glucoside in vitro suppresses NFκB and changes the secretome of mesenchymal stem cells affecting macrophage activation,Nutrition,2022,111853,ISSN 0899-9007, |
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| Cas No. | 6906-38-3 | SDF | |
| Synonyms | Delphinidin-3-β-D-glucoside chloride, Delphinidin-3-O-glucoside, Delphinin | ||
| Canonical SMILES | OC(C=C1O)=CC2=C1C=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C(C4=CC(O)=C(O)C(O)=C4)=[O+]2.[Cl-] | ||
| Formula | C21H21O12•Cl | M.Wt | 500.8 |
| Solubility | DMF: 1.5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 0.2 mg/ml | Storage | Store at -20°C, sealed storage, away from moisture and light |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9968 mL | 9.984 mL | 19.9681 mL |
| 5 mM | 399.4 μL | 1.9968 mL | 3.9936 mL |
| 10 mM | 199.7 μL | 998.4 μL | 1.9968 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)