GLPBio

NADPH Oxidase

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NADPH oxidase (NOX) is a transmembrane enzyme that is located in intracellular organelles. NADPH oxidase (NOX) enzymes are membrane-bound proteins that catalyze the conversion of oxygen to superoxide. There are a number of isoforms, NOX1-5 and dual oxidases 1 and 2 (DUOX1-2), which have diverse functions. NOX1, NOX2, NOX4, and NOX5 are expressed in human vascular tissue. NOX1 and NOX2 are regulated by cytosolic components loosely termed as activators or organizers, which are generally recruited to the membrane components following cellular stimuli to assemble an active NOX. Molecular switch from NOX1 to NOX2 in colon cancer cells induces ROS production and subsequently enhances MMP-7 expression by deactivating AMPK. Vascular NOX4 is a multifarious NADPH oxidase. NOX4 is a hydrogen peroxide-generating oxygen sensor.

Products Related to NADPH Oxidase(16)

  • GC11882 structure
    GC11882GKT137831
    CAS: 1218942-37-0
    Purity: >99.00%

    GKT137831, an orally dual NADPH oxidase 1/4 (NOX1/NOX4) inhibitor with potency in the submicromolar range, could prevent oxidative stress in human aortic endothelial cells induced by hyperglycemia and attenuate the development of atherosclerosis in diabetic mice.

  • GC12291 structure
    GC12291ML 171
    CAS: 6631-94-3
    Purity: >99.50%

    NADPH oxidase 1 (NOX1) inhibitor

  • GC12323 structure
    GC12323ML-090
    CAS: 531-46-4
    Purity: >98.00%

    ML-090 (ML-090) is a selective NOX1 inhibitor with an IC50of 90 nM.

  • GC12520 structure
    GC12520Diphenyleneiodonium chloride
    CAS: 4673-26-1
    Purity: >99.50%

    Diphenyleneiodonium chloride (DPI), as a NADH/NADPH oxidase inhibitor, has possessing potent antimicrobial activity against Mycobacterium tuberculosis and Staphylococcus aureus.

  • GC31367 structure
    GC31367GLX351322
    CAS: 835598-94-2
    Purity: >99.50%

    GLX351322 is a NADPH Oxidase 4 (NOX4) inhibitor, with an IC 50 value of 5μM.

  • GC32443 structure
    GC32443VAS2870
    CAS: 722456-31-7
    Purity: >98.50%

    A pan-NADPH oxidase inhibitor

  • GC32681 structure
    GC32681GSK2795039
    CAS: 1415925-18-6
    Purity: >98.00%

    GSK2795039 is a potent inhibitor of NADPH oxidase 2 (NOX2) enzyme with an IC 50 value of 0.18μM.

  • GC38115 structure
    GC38115APX-115 free base
    CAS: 1270084-92-8
    Purity: >99.00%

    APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.

  • GC38353 structure
    GC38353APX-115
    CAS: 1395946-75-4
    Purity: >98.00%

    APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.

  • GC50281 structure
    GC50281NoxA1ds
    CAS: 1435893-78-9
    Purity: >98.50%

    Potent and selective NADPH oxidase 1 (NOX1) inhibitor

  • GC62989 structure
    GC62989GKT136901 hydrochloride
    CAS: 1254507-01-1
    Purity: >99.50%

    GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively.

  • GC63986 structure
    GC63986VAS 3947
    CAS: 869853-70-3
    Purity: >99.00%
  • GC71188 structure
    GC71188NADPH oxidase-IN-1
    CAS: 2762405-17-2
    Purity: >99.00%

    NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation.

  • GC71289 structure
    GC71289GLX481304
    CAS: 701224-63-7
    Purity: >99.00%

    GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM.

  • GC79718 structure
    GC79718NCATS-SM7270
    Purity: >99.00%

    NCATS-SM7270 is a highly specific NOX2 inhibitor, with an IC 50 of 4.09 μM.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.