Neuropeptide FF/AF Receptors
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Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.
Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.
Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. A number of other uses for modulators of NPY receptors have been implied in a range of diseases.
Products Related to Neuropeptide FF/AF Receptors(51)
- GA20195(Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human)CAS: 313988-89-5Purity: >98%
(Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human) is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor.
- GA20229(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat)CAS: 132699-73-1Purity: >98%
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist.
- GC10862Galanin (1-30) (human)CAS: 119418-04-1Purity: >98.00%
Endogenous peptide with multiple endocrine, metabolic and behavioral effects
- GC13167Pancreatic Polypeptide (human)CAS: 75976-10-2Purity: >99.50%
Endogenous high affinity agonist for human NPY Y4 receptor
- GC14612JNJ-31020028CAS: 1094873-14-9Purity: >98.00%
selective brain penetrant antagonist of neuropeptide Y2 receptor
- GC15408Neuropeptide AF (human)CAS: 192387-38-5Purity: >98%
Endogenous antiopioid peptide implicated in pain modulation and endocrine functions
- GC30452Peptide YY (PYY), humanCAS: 118997-30-1Purity: >97.00%
Peptide YY (PYY), human is a peptide hormone secreted by intestinal L cells.
- GC30456Pancreatic Polypeptide, bovineCAS: 179986-89-1Purity: >98%
Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.
- GC30947Galanin (1-16), mouse, porcine, ratCAS: 125118-77-6Purity: >98%
Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GA20195 | (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) | 313988-89-5 | >98% | |
(Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human) is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. | ||||
| GA20229 | (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) | 132699-73-1 | >98% | |
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist. | ||||
| GA23511 | Spexin | 1370290-58-6 | >98.00% | |
Spexin is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. | ||||
| GC10167 | CGP 71683 hydrochloride | 192322-50-2 | >99.00% | |
NPY Y5 receptor antagonist | ||||
| GC10862 | Galanin (1-30) (human) | 119418-04-1 | >98.00% | |
Endogenous peptide with multiple endocrine, metabolic and behavioral effects | ||||
| GC12648 | Neuropeptide FF | 99566-27-5 | >99.50% | |
agonist at NPFF1 and NPFF2 receptors | ||||
| GC13167 | Pancreatic Polypeptide (human) | 75976-10-2 | >99.50% | |
Endogenous high affinity agonist for human NPY Y4 receptor | ||||
| GC13801 | M40 | 143896-17-7 | >98% | |
M40, a peptidergic galanin antagonist, is a 29 amino acid neuropeptide that is widely distributed in the central nervous system of both rats and humans. | ||||
| GC13864 | Neuropeptide SF (mouse, rat) | 230960-31-3 | >98% | |
neuropeptide FF receptor agonist | ||||
| GC14112 | RFRP 3 (human) | 311309-27-0 | >98.50% | |
NPFF1 receptor agonist | ||||
| GC14430 | JNJ 5207787 | 683746-68-1 | >98% | |
NPY Y2 antagonist | ||||
| GC14612 | JNJ-31020028 | 1094873-14-9 | >98.00% | |
selective brain penetrant antagonist of neuropeptide Y2 receptor | ||||
| GC14881 | BMS 193885 | 679839-66-8 | >99.00% | |
Competitive NPY Y1 receptor antagonist | ||||
| GC15408 | Neuropeptide AF (human) | 192387-38-5 | >98% | |
Endogenous antiopioid peptide implicated in pain modulation and endocrine functions | ||||
| GC15469 | RF 9 | 876310-60-0 | >98.50% | |
neuropeptide FF receptors antagonist | ||||
| GC15633 | Neuropeptide SF (human) | 192387-39-6 | >98% | |
Endogenous antiopiate neuropeptide | ||||
| GC16987 | L-152,804 | 6508-43-6 | >99.50% | |
neuropeptide Y Y5 receptor antagonist | ||||
| GC17307 | CYM 9484 | 1383478-94-1 | >99.00% | |
neuropeptide Y (NPY) Y2 receptor antagonist | ||||
| GC17424 | BIIE 0246 | 246146-55-4 | >99.50% | |
NPY Y2 receptor antagonist | ||||
| GC30452 | Peptide YY (PYY), human | 118997-30-1 | >97.00% | |
Peptide YY (PYY), human is a peptide hormone secreted by intestinal L cells. | ||||
| GC30456 | Pancreatic Polypeptide, bovine | 179986-89-1 | >98% | |
Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4. | ||||
| GC30721 | FR252384 | 447405-11-0 | >98% | |
FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM. | ||||
| GC30931 | Galantide | 138579-66-5 | >99.00% | |
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. | ||||
| GC30947 | Galanin (1-16), mouse, porcine, rat | 125118-77-6 | >98% | |
Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. | ||||