Neuroprotection

5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.

Leteprinim (potassium salt) (AIT-082) is a hypoxanthine derivative neurotrophic agent.

A neuroprotective agent

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.

ML221 is a potent apelin (APJ) functional antagonist

(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.

Ginsenoside CK, a secondary ginsenoside biotransformed from major ginsenosides, is more bioavailable and soluble than its parent ginsenosides and holds great significance.

Kynurenic acid-d5 is the deuterium labeled Kynurenic acid.

An AT 2 receptor agonist

ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM.

Totarol is a non-specific inhibitor of the bacterial cell division protein FtsZ.

Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor.

CMS121 is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.

Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism.

Orsellinic acid is a fungal metabolite and benzoic acid derivative with antioxidant and neuroprotective activities.

1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence.

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets.

4-Aminobenzoic Acid hydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 μM.

N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine.

Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties.

Gallotannin (Tannic acid) is a natural polyphenolic compound that has been found in various plants and has antioxidant, anti-inflammatory, anti-angiogenic, antiviral and anti-tumor biological activities. Gallotannin inhibits the activity of DNA polymerase α, β and κ with IC 50 values of 13, 130 and 30nM, respectively .

nNOS Inhibitor I is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM.

PAQ is a neuroprotective agent.

Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM).