NSC 689534 |
| Catalog No.GC73702 |
NSC 689534 can form copper chelate with Cu2+.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 907958-80-9
Sample solution is provided at 25 µL, 10mM.
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NSC 689534 can form copper chelate with Cu2+. NSC 689534/Cu2+ complex is a potent oxidative stress inducer, and has antitumor activity.
NSC 689534/Cu2+ complex (48 h) inhibits cell viability of HL60 and PC3 cell with IC50s of 0.2 and 0.4 μM respectively, which is about 4 times more potent than NSC 689534 alone[1].NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces oxidative stress and depletes GSH in PC3 cells, whereas with no effect by NSC 689534 alone[1].NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces macroautophagy (indicated by LC3 accumulation into large autophagosomes) and an ER-stress response (upregulation of GRP78 and CHOP) in PC3 cells[1].
NSC 689534/Cu2+ complex (3 mg/kg, i.p., once or twice a day for 5 days) inhibits tumor growth in HL60 xenograft model, whereas with no statistical significance by NSC 689534 alone[1].
References:
[1]. Chad N Hancock, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.
[2]. Hancock CN, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.
| Cas No. | 907958-80-9 | SDF | |
| Formula | C19H18N6S | M.Wt | 362.45 |
| Solubility | Storage | -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.759 mL | 13.795 mL | 27.59 mL |
| 5 mM | 0.5518 mL | 2.759 mL | 5.518 mL |
| 10 mM | 0.2759 mL | 1.3795 mL | 2.759 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >96.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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