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ONO 2506 (Synonyms: ONO-2506)

Catalog No.GC10652

Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis.

Products are for research use only. Not for human use. We do not sell to patients.

ONO 2506 Chemical Structure

Cas No.: 185517-21-9

Size Price Stock Qty
10mM (in 1mL DMSO)
$46.00
In stock
10mg
$102.00
In stock
25mg
$167.00
In stock
50mg
$260.00
In stock
100mg
$464.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 2 publications

Product Documents

Quality Control & SDS

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Background

Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid (ONO-2506) has been developed as a therapeutic agent for stroke and Alzheimer’s disease[1][2][3].

References:
[1]. Tomoyuki Hasegawa, et al. Process Development of ONO-2506:  A Therapeutic Agent for Stroke and Alzheimer's Disease. Org. Process Res. Dev.200372168-171.
[2]. Kato H, et al. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTPneurotoxicity in mice. Brain Res. 2004 Dec 24;1030(1):66-73.

Chemical Properties

Cas No. 185517-21-9 SDF
Synonyms ONO-2506
Chemical Name (R)-2-propyloctanoic acid
Canonical SMILES OC([C@H](CCC)CCCCCC)=O
Formula C11H22O2 M.Wt 186.29
Solubility <18.63mg/ml in DMSO; <18.63mg/ml in ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.368 mL 26.8399 mL 53.6797 mL
5 mM 1.0736 mL 5.368 mL 10.7359 mL
10 mM 0.5368 mL 2.684 mL 5.368 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for ONO 2506

Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

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