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Oxytocin Receptors

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Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

Products Related to Oxytocin Receptors(22)

  • GC11042 structure
    GC11042WAY 267464 dihydrochloride
    CAS: 847375-16-0
    Purity: >98%

    WAY 267464 dihydrochloride is a non-peptide oxytocin receptor (OTR) agonist.

  • GC11419 structure
    GC11419Carbetocin
    CAS: 37025-55-1
    Purity: >98.00%

    oxytocin receptor agonist

  • GC11991 structure
    GC11991L-371,257
    CAS: 162042-44-6
    Purity: >99.00%

    human oxytocin (OT) receptor antagonist

  • GC12194 structure
    GC12194Atosiban
    CAS: 90779-69-4
    Purity: >99.00%

    Atosiban is a mixed antagonist of oxytocin and vasopressin receptors. It effectively inhibits uterine contractions and prolongs pregnancy by competitively blocking oxytocin receptors on uterine smooth muscle.

  • GC14001 structure
    GC14001TC OT 39
    CAS: 479232-57-0
    Purity: >98%

    oxytocin receptor partial agonist

  • GC16222 structure
    GC16222Oxytocin
    CAS: 50-56-6
    Purity: >98.00%

    Oxytocin is a pleiotropic hypothalamic peptide that helps in childbirth, lactation and prosocial behavior.

  • GC16620 structure
    GC16620L-368,899 hydrochloride
    CAS: 160312-62-9
    Purity: >97.00%

    L-368,899 hydrochloride is an orally active and selective OT (oxytocin ) receptor antagonist, with IC50s of 8.9 and 26 nM for uterus of rat and human, respectively.

  • GC17249 structure
    GC17249PF-3274167
    CAS: 900510-03-4
    Purity: >98.00%

    Oral oxytocin antagonist

  • GC30594 structure
    GC30594Epelsiban (GSK 557296)
    CAS: 872599-83-2
    Purity: >98%

    Epelsiban (GSK 557296) (GSK 557296) is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor.

  • GC31068 structure
    GC31068Retosiban (GSK 221149)
    CAS: 820957-38-8
    Purity: >98.50%

    Retosiban (GSK 221149) (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.

  • GC32425 structure
    GC32425OT antagonist 1
    CAS: 479080-38-1
    Purity: >98%

    OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.

  • GC32431 structure
    GC32431OT antagonist 3
    CAS: 925703-75-9
    Purity: >98%

    OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1.

  • GC33540 structure
    GC33540OT-R antagonist 2 (Oxytocin receptor antagonist 2)
    CAS: 364071-16-9
    Purity: >98%

    OT-R antagonist 2 (Oxytocin receptor antagonist 2) is a nonpeptide low molecular weight OT-R antagonist.

  • GC34364 structure
    GC34364OT antagonist 1 demethyl derivative
    CAS: 2763705-17-3
    Purity: >98%

    OT antagonist 1 demethyl derivative is the demethyl derivative of OT antagonist 1.

  • GC36823 structure
    GC36823OT-R antagonist 1
    CAS: 364071-17-0
    Purity: >98.00%

    OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist.

  • GC37635 structure
    GC37635SHR1653
    CAS: 2231770-73-1
    Purity: >98%

    SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR.

  • GC38922 structure
    GC38922LIT-001
    CAS: 2245072-21-1
    Purity: >98.50%

    LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).

  • GC39849 structure
    GC39849Atosiban acetate
    CAS: 914453-95-5
    Purity: >99.50%

    Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue.

  • GC44526 structure
    GC44526Oxytocin (acetate)
    CAS: 6233-83-6
    Purity: >95.00%

    Oxytocin is a nonapeptide hormone primarily synthesized in magnocellular neurons of the paraventricular and supraoptic nuclei of the hypothalamus.

  • GC63036 structure
    GC63036L-372662
    CAS: 162045-26-3
    Purity: >98.50%

    L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8.

  • GC68698 structure
    GC68698[Asp5]-Oxytocin
    CAS: 65907-78-0
    Purity: >99.00%

    [Asp5]-Oxytocin is a highly potent 5-position-neurohypophysial hormone analog. It can induce uterine contractions in vitro in rats and can be enhanced by magnesium ions. [Asp5]-Oxytocin has the ability to act as a rat uterotonic, avian vasopressin inhibitor, and rat antidiuretic agent.

  • GC74398 structure
    GC74398Vasopressin Dimer (parallel) (TFA)
    Purity: >99.00%

    Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin.