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PAI-1

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Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and functionally serves to suppress tissue and plasma fibrinolysis.

PAI-1 is a member of the serpin family of proteins and exists in multiple conformations of which a minor component, the “active” form, exhibits inhibitory effects against tPA and uPA.

PAI-1 is an endogenous inhibitor of urokinase-type plasminogen activator (uPA), and its expression is regulated by a number of intrinsic factors (e.g., cytokines and growth factors) and extrinsic factors (e.g., cellular stress).

PAI-1 seems to play a pivotal role in tumor growth and may represent a potential therapeutic target for bladder cancer.

Products Related to PAI-1(19)

  • GA21910 structure
    GA21910Glutaryl-Gly-Arg-AMC
    CAS: 65147-16-2
    Purity: >98.50%

    Glutaryl-Gly-Arg-AMC is a fluorescent substrate and a peptide substrate of urokinase plasminogen activator (uPA). The maximum excitation/emission wavelength of the fluorophore AMC is 380nm/460nm.

  • GA22381 structure
    GA22381GGACK (H-Glu-Gly-Arg-chloromethylketone)
    CAS: 65113-67-9
    Purity: >98.00%

    GGACK (H-Glu-Gly-Arg-chloromethylketone) is an irreversible serine protease inhibitor. GGACK can inhibit urokinase-type plasminogen activator (uPA) and block the plasminogen activation process.

  • GC12387 structure
    GC12387Tiplaxtinin(PAI-039)
    CAS: 393105-53-8
    Purity: >98.00%

    Tiplaxtinin(PAI-039) is an orally bioavailable antagonist of plasminogen activator inhibitor-1 (PAI-1) with IC 50 value of 2.7μM.

  • GC18173 structure
    GC18173TM5441
    CAS: 1190221-43-2
    Purity: >98.00%

    TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC 50 values between 13.9 and 51.1μM and induces intrinsic apoptosis in several human cancer cell lines.

  • GC19358 structure
    GC19358TM5275 sodium
    CAS: 1103926-82-4
    Purity: >98.00%

    TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 uM.

  • GC31889 structure
    GC31889ZK824859
    CAS: 2271122-53-1
    Purity: >98%

    ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively.

  • GC34324 structure
    GC34324ZK824859 hydrochloride
    Purity: >99.00%

    ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively.

  • GC38971 structure
    GC38971Toddalolactone
    CAS: 483-90-9
    Purity: >98.00%

    Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM.

  • GC44671 structure
    GC44671PPACK
    CAS: 71142-71-7
    Purity: >98.00%

    PPACK is a potent selective and irreversible thrombin inhibitor that inhibits human alpha thrombin with a K i value of 0.24 nM.

  • GC61511 structure
    GC61511Angstrom6
    CAS: 220334-14-5
    Purity: >99.00%

    Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.

  • GC65281 structure
    GC65281Aleplasinin
    CAS: 481629-87-2
    Purity: >99.00%

    Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor.

  • GC67781 structure
    GC67781Diaplasinin
    CAS: 481631-45-2
    Purity: >99.00%
  • GC68013 structure
    GC68013CDE-096
    CAS: 1228357-04-7
    Purity: >98%
  • GC70534 structure
    GC70534PPACK TFA
    CAS: 157379-44-7
    Purity: >99.00%

    PPACK TFA is a plasminogen activator (rt-PA) inhibitor.

  • GC72878 structure
    GC72878UCD38B hydrochloride
    CAS: 1115177-19-9
    Purity: >99.00%

    UCD38B drochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM.

  • GC79732 structure
    GC79732D-Val-Leu-Lys-AMC TFA
    Purity: >99.50%

    D-Val-Leu-Lys-AMC TFA is a selective fluorogenic peptide substrate of plasmin.

  • GC79737 structure
    GC79737(S)-ZK824859 hydrochloride
    CAS: 2724549-24-8
    Purity: >98.00%

    (S)-ZK824859 hydrochloride is a uPA inhibitor and anticoagulant.

  • GC79758 structure
    GC79758PAI-1-IN-1
    CAS: 1247823-40-0
    Purity: >99.00%

    PAI-1-IN-1 is an orally active and specific PAI-1 inhibitor with an IC 50 of <6.95 μM.

  • GN10267 structure
    GN10267Loureirin B
    CAS: 119425-90-0
    Purity: >99.00%