PARL-IN-2 (Compound 14) is a covalent inhibitor of the mitochondrial intramembrane protease PARL with an EC 50 value of 0.16 μM. PARL-IN-2 leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-2 promotes PINK1/Parkin -dependent mitophagy [1].
References:
[1]. Ji S, Bach K, et al. 4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL[J]. ACS Medicinal Chemistry Letters, 2024.
References:
[1]. Ji S, Bach K, et al. 4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL[J]. ACS Medicinal Chemistry Letters, 2024.