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Mitophagy

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Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products Related to Mitophagy(84)

  • GA10942 structure
    GA10942H-D-Gln-OH
    CAS: 5959-95-5
    Purity: >99.00%
  • GC10200 structure
    GC10200Mdivi 1
    CAS: 338967-87-6
    Purity: >98.00%

    Mdivi-1 (Mitochondrial division inhibitor 1) inhibits traumatic brain injury (TBI)-induced dynamin-related protein 1(Drp1) up-regulation, autophagy dysfunction and mitophagy activation.

  • GC10480 structure
    GC10480Betulinic acid
    CAS: 472-15-1
    Purity: >98.00%

    Betulinic acid is a natural pentacyclic triterpenoid compound and an inhibitor of eukaryotic topoisomerase I with an IC 50 value of 5 μM.

  • GC10518 structure
    GC10518AICAR
    CAS: 2627-69-2
    Purity: >99.00%

    AICAR (also called acadesine) is a purine nucleoside.

  • GC10580 structure
    GC10580AICAR phosphate
    CAS: 681006-28-0
    Purity: >98.00%

    AMPK activator

  • GC10585 structure
    GC10585Simvastatin (Zocor)
    CAS: 79902-63-9
    Purity: >98.00%

    Simvastatin (Zocor) (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.

  • GC10710 structure
    GC107103-Methyladenine
    CAS: 5142-23-4
    Purity: >98.00%

    3-Methyladenine is a PI3K inhibitor with IC 50 values of 25μM and 60μM for Vps34 and PtdIns3Kγ, respectively.

  • GC11237 structure
    GC11237Dexamethasone acetate
    CAS: 1177-87-3
    Purity: >98.00%

    IL Receptor modulator

  • GC11332 structure
    GC11332Pitavastatin
    CAS: 147511-69-1
    Purity: >98.00%

    Pitavastatin is a 3-Hydroxymethyl-3-glutaryl-CoA (HMG-CoA) reductase inhibitors. The IC 50 value of the HMG-CoA reductase activity in the Hep G2 cells for Pitavastatin was 5.8nM.

  • GC11424 structure
    GC11424Valproic acid
    CAS: 99-66-1
    Purity: >98.00%

    HDAC1 inhibitor

  • GC11720 structure
    GC1172017-AAG (KOS953)
    CAS: 75747-14-7
    Purity: >98.00%

    17-AAG (KOS953) is a potent Hsp90 inhibitor (IC 50 =5nM).

  • GC12017 structure
    GC12017Isoniazid
    CAS: 54-85-3
    Purity: >99.50%

    antibiotic used for the treatment of tuberculosis

  • GC12116 structure
    GC12116Pitavastatin Calcium
    CAS: 147526-32-7
    Purity: >99.00%

    Enzyme HMGCR inhibitor

  • GC12339 structure
    GC12339Ivermectin
    CAS: 70288-86-7
    Purity: >98.00%

    Ivermectin is a macrolide endectocide with activity against both endoparasites and ectoparasites.

  • GC12495 structure
    GC12495Olanzapine
    CAS: 132539-06-1
    Purity: >99.50%

    Olanzapine is a monoamine antagonist.

  • GC12807 structure
    GC12807U0126-EtOH
    CAS: 1173097-76-1
    Purity: >98.00%

    U0126-EtOH is a non-ATP competitive and selective inhibitor of MEK1 and MEK2 with IC 50 values of 72nM and 58nM, respectively.

  • GC13001 structure
    GC13001SB 203580 hydrochloride
    CAS: 869185-85-3
    Purity: >98.00%

    Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively.

  • GC13443 structure
    GC13443Doxazosin Mesylate
    CAS: 77883-43-3
    Purity: >99.50%

    α1-adrenergic receptor antagonist

  • GC13554 structure
    GC13554Deferoxamine mesylate
    CAS: 138-14-7
    Purity: >98.00%

    Deferoxamine mesylate is an iron chelator that binds Fe(III) and many other metal cations.

  • GC13595 structure
    GC13595SB 203580
    CAS: 152121-47-6
    Purity: >99.00%

    SB 203580 is a specific inhibitor of p38-MAPK (Mitogen-activated Protein Kinase) pathway .

  • GC14191 structure
    GC14191Ruxolitinib (INCB18424)
    CAS: 941678-49-5
    Purity: >98.00%

    Ruxolitinib (INCB018424), as an inhibitor, inhibits Janus-associated kinases (JAKs)JAK1 and JAK2 with IC 50 values of 3.3 nM and 2.8 nM, respectively.

  • GC14553 structure
    GC14553Resveratrol
    CAS: 501-36-0
    Purity: >99.50%

    Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin.

  • GC14591 structure
    GC14591Hemin chloride
    CAS: 16009-13-5
    Purity: >98.00%

    Hemin chloride, a substrate of heme oxygenase (HO)-1, induces HO-1 expression on a variety of cells to exert anti-oxidant and anti-inflammatory roles.

  • GC14787 structure
    GC14787Curcumin
    CAS: 458-37-7
    Purity: >98.00%

    A yellow pigment with diverse biological activities