Pavinetant (MLE-4901) (Synonyms: AZD 2624, AZD 4901) |
Catalog No.GC30861 |
Pavinetant (MLE-4901) (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 941690-55-7
Sample solution is provided at 25 µL, 10mM.
Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.
Pavinetant (AZD2624) is a potent and selective NK3 receptor antagonist which is developed for the treatment of schizophrenia. Pavinetant exhibits an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC50 values of 7.1 and 19.8 μM for midazolam and testosterone assays, respectively. No time-dependent inactivation of CYP3A4/5 activity by Pavinetant is observed. Pavinetant demonstrates weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6[1].
[1]. Li Y, et al. In vitro assessment of metabolic drug-drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies. Xenobiotica. 2010 Nov;40(11):721-9.
Average Rating: 5
(Based on Reviews and 24 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *