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VLX600

Catalog No.GC17093

shows selective cytotoxicity against quiescent cancer cells

Products are for research use only. Not for human use. We do not sell to patients.

VLX600 Chemical Structure

Cas No.: 327031-55-0

Size Price Stock Qty
1mg
$19.00
In stock
5mg
$57.00
In stock
10mg
$92.00
In stock
25mg
$194.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

VLX600 is a compound that is preferentially active against quiescent cancer cells [1].

Abnormal vascularization of solid tumors lead to the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells, which display enhanced resistance to standard chemotherapeutic agents and repopulate tumours after therapy [1].

VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation and displays tumour growth inhibition in vivo. In HCT116 colon carcinoma multicellular spheroids (MCS), VLX600 resulted in the appearance of central necrotic areas, induced active caspase-3 and led to a strong decrease in clonogenicity of dispersed cells. VLX600 also induced the expression of genes associated with hypoxia, glycolysis and p53 signaling. In HCT116 cells, VLX600 induces an autophagic response [1].

In NMRI nu/nu mice mice, VLX600 was rapidly distributed and finally eliminated with a half-life of 4-5 h. In mice bearing HCT116 and HT29 colon cancer xenografts, VLX600 exhibited antitumour activity and induced the formation of autolysosomes [1].

Reference:
[1].Zhang X, Frykns M, Hernlund E, et al.  Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295.

Chemical Properties

Cas No. 327031-55-0 SDF
Chemical Name 1-(2-pyridinyl)-ethanone, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone
Canonical SMILES C/C(C1=NC=CC=C1)=N/NC2=NC3=C(C(C=CC=C4C)=C4N3)N=N2
Formula C17H15N7 M.Wt 317.4
Solubility ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide Storage Store at -20°C,unstable in solution, ready to use.
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.1506 mL 15.753 mL 31.506 mL
5 mM 0.6301 mL 3.1506 mL 6.3012 mL
10 mM 0.3151 mL 1.5753 mL 3.1506 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

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