GLPBio

PC-766B

Catalog No.: GC11393Purity:>98%Synonyms: Antibiotic PC-766B
COASDSData Sheet
macrolide antibiotic

Products are for research use only. Not for human use. We do not sell to patients.

PC-766B
Cas No.: 108375-77-5
1mgIn Stock
$353.00
1
5mgIn Stock
$1,411.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

PC-766B is a macrolide antibiotic existed in anactinomycete strain SC-4710.

PC-766B was active against Gram-positive bacteria, and some fungi and yeasts, yet inactive against Gram-negative bacteria. PC-766B exhibited potent cytotoxicity against murine tumor cell lines in vitro. The IC50 values against P388 leukemia and B16 melanoma were 0.1 and 0.5 ng/ml, respectively [1]. Intraperitoneal administration of PC-766B (0.25mg/kg/day) showed in vivo antitumor activity against P388 leukemia. PC-766B showed a weak inhibitory activity against Na+, K+-ATPase [1].

Reference:
[1] KUMAGAI K, TAYA K, FUKUI A, et al.  PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY Nocardia brasiliensis[J]. The Journal of antibiotics, 1993, 46(6): 972-978.

Chemical Properties

CAS No.
108375-77-5
Synonyms
Antibiotic PC-766B
Chemical Name
16-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[(2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]tetrahydro-2-hydroxy-5-methyl-6-[(1E,3E)-1,3-pentadien-1-yl]-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-(3Z,5E,7R,8S,9S,11E,13E,15S,16
SMILES
O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)O)O)[C@H](C)[C@@H](/C=C/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC
Molecular Formula
C43H68O12
Molecular Weight
777
Solubility
DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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