PZ-2891 |
| Catalog No.GC34746 |
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2170608-82-7
Sample solution is provided at 25 µL, 10mM.
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PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA. IC50: 1.3 nM (PANK)[1]
[1]. Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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