PDHK

PDHK (pyruvate dehydrogenase kinase) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.

Products Related to PDHK(10)

GC13669 AZD7545
CAS: 252017-04-2
Purity: >99.50%
AZD7545 is a competitive pyruvate dehydrogenase kinase 2 (PDHK2) inhibitor (IC₅₀=6.4nM) that also inhibits PDHK1 activity (IC₅₀=36.8nM).
GC15350 Dicoumarol
CAS: 66-76-2
Purity: >98.00%
competitive NADH quinone oxidoreductase (NQO1) inhibitor
GC16795 DCA
CAS: 2156-56-1
Purity: >98.00%
DCA is a metabolic regulator in cancer cells' mitochondria with anticancer activity. DCA inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. DCA increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. DCA also works as NKCC inhibitor.
GC32778 VER-246608
CAS: 1684386-71-7
Purity: >98.50%
A pan-PDHK inhibitor
GC36396 KPLH1130
CAS: 906669-07-6
Purity: >98.00%
KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.
GC39500 PDK4-IN-1 hydrochloride
CAS: 2310262-11-2
Purity: >98.00%
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM.
GC50280 JX 06
CAS: 729-46-4
Purity: >99.50%
Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor
GC60232 M77976
CAS: 394237-61-7
Purity: >98.00%
M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM.
GC65502 TM-1
CAS: 921099-13-0
Purity: >98%
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation.
GC73738 PDK-IN-3
Purity: >99.00%
PDK-IN-3 (compound 1) is a potent pan inhibitor of PDK with IC50s of 109.3, 135.8, 458.7 nM and 8.67 μM against PDK 1-4, respectively.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC13669	AZD7545	252017-04-2	>99.50%
GC13669	AZD7545 is a competitive pyruvate dehydrogenase kinase 2 (PDHK2) inhibitor (IC₅₀=6.4nM) that also inhibits PDHK1 activity (IC₅₀=36.8nM).
GC15350	Dicoumarol	66-76-2	>98.00%
GC15350	competitive NADH quinone oxidoreductase (NQO1) inhibitor
GC16795	DCA	2156-56-1	>98.00%
GC16795	DCA is a metabolic regulator in cancer cells' mitochondria with anticancer activity. DCA inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. DCA increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. DCA also works as NKCC inhibitor.
GC32778	VER-246608	1684386-71-7	>98.50%
GC32778	A pan-PDHK inhibitor
GC36396	KPLH1130	906669-07-6	>98.00%
GC36396	KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.
GC39500	PDK4-IN-1 hydrochloride	2310262-11-2	>98.00%
GC39500	PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM.
GC50280	JX 06	729-46-4	>99.50%
GC50280	Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor
GC60232	M77976	394237-61-7	>98.00%
GC60232	M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM.
GC65502	TM-1	921099-13-0	>98%
GC65502	TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation.
GC73738	PDK-IN-3	-	>99.00%
GC73738	PDK-IN-3 (compound 1) is a potent pan inhibitor of PDK with IC50s of 109.3, 135.8, 458.7 nM and 8.67 μM against PDK 1-4, respectively.