PDK-1
PDK-1 (3-phosphoinositide dependent protein kinase-1) is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK.
Products Related to PDK-1(16)
- GC15615BX517(PDK1 inhibitor2)CAS: 850717-64-5Purity: >98.00%
BX517(PDK1 inhibitor2) is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
- GC63802(R)-PS210CAS: 1410101-89-1Purity: >98.00%
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment.
- GC66474PDK1-IN-RS2CAS: 1643958-89-7Purity: >98%
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.
- GC69714PKD-IN-1 dihydrochlorideCAS: 2308510-39-4Purity: >99.00%
PKD-IN-1 dihydrochloride (compound 32) is an aminoethylaminobenzyl (AEAA) compound that can be used as a PKD-1 inhibitor. PKD-IN-1 can be used in research on diseases mediated by protein kinase D (PKD).
- GC80872PDKtide TFAPurity: >98.50%
PDKtide TFA, a biological active peptide, is a substrate for phosphatidylinositide-dependent kinase 1 ( PDK1 ) [1] .
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC12275 | GSK2334470 | 1227911-45-6 | >99.50% | |
PDK1 inhibitor,highly specific and potent | ||||
| GC15742 | OSU-03012 (AR-12) | 742112-33-0 | >98% | |
Potent PDK1 inhibitor | ||||
| GC16818 | BX-912 | 702674-56-4 | >99.50% | |
PDK1 inhibitor,potent and ATP-competitive | ||||
| GC10857 | UCN-01 | 112953-11-4 | >98% | |
inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases | ||||
| GC11573 | BX795 | 702675-74-9 | >99.00% | |
BX795 is an inhibitor of 3-phosphoinositide-dependent protein kinase 1 (PDK1), with an IC 50 value of 11nM. | ||||
| GC12866 | PDK1 inhibitor | 1001409-50-2 | >99.50% | |
| GC13725 | NVP-BAG956 | 853910-02-8 | >98% | |
A dual PDK1 and class I PI3K inhibitor | ||||
| GC13920 | PS 48 | 1180676-32-7 | >98.00% | |
PS 48 is a PDK1 (phosphoinositide-dependent kinase-1) activator with an AC 50 of 8μM. PS 48 can bind to the HM/PIF binding pocket of PDK1, targeting the protein kinase catalytic domain without affecting the ATP binding site. | ||||
| GC15615 | BX517(PDK1 inhibitor2) | 850717-64-5 | >98.00% | |
BX517(PDK1 inhibitor2) is a potent and selective inhibitor of PDK1 with IC50 of 6 nM. | ||||
| GC63155 | PS47 | 1180676-33-8 | >98.00% | |
PS47 is an inactive E-isomer of PS48. | ||||
| GC63802 | (R)-PS210 | 1410101-89-1 | >98.00% | |
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment. | ||||
| GC66474 | PDK1-IN-RS2 | 1643958-89-7 | >98% | |
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1. | ||||
| GC69714 | PKD-IN-1 dihydrochloride | 2308510-39-4 | >99.00% | |
PKD-IN-1 dihydrochloride (compound 32) is an aminoethylaminobenzyl (AEAA) compound that can be used as a PKD-1 inhibitor. PKD-IN-1 can be used in research on diseases mediated by protein kinase D (PKD). | ||||
| GC72885 | PDK1-IN-2 | 1643958-85-3 | >98.00% | |
PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1). | ||||
| GC80872 | PDKtide TFA | - | >98.50% | |
PDKtide TFA, a biological active peptide, is a substrate for phosphatidylinositide-dependent kinase 1 ( PDK1 ) [1] . | ||||
| GN10709 | Polyphyllin A | 50773-41-6 | >98.00% | |