GLPBio

PDK1-IN-2

Catalog No.: GC72885Purity:>98.00%
COASDSData Sheet
PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1).

Products are for research use only. Not for human use. We do not sell to patients.

PDK1-IN-2
Cas No.: 1643958-85-3
1 mgIn Stock
$221.00
1
5 mgIn Stock
$536.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1). PDK1-IN-2 inhibits the binding of PDK1 to its substrate by competitively binding to the PIF pocket of PDK1, thereby inhibiting the kinase activity and downstream signaling of PDK1. PDK1-IN-2 can be used for cell survival and proliferation in cancer.

References:
[1]. Rettenmaier T J, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1[J]. Proceedings of the National Academy of Sciences, 2014, 111(52): 18590-18595.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1643958-85-3
Molecular Formula
C15H9ClN2O2S3
Molecular Weight
380.89
Solubility
DMSO : 4 mg/mL (10.50 mM; Need ultrasonic and warming)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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