PI3K/Akt/mTOR Signaling

Torin 1 is a potent ATP-competitive mammalian target of rapamycin (mTOR) inhibitor with an IC 50 value of 3nM.

ATR inhibitor,potent and selective

MELK inhibitor

TIC10 isomer is the analogue of TIC10/ONC201.

PI 3-Kinase inhibitor

Antidiabetic agent

AMPK activator

PF-4708671, is a novel cell-permeable inhibitor of S6K1, specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM.

IPI-145 (INK1197) (IPI-145) is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.

Imeglimin hydrochloride is an oral glucose-lowering agents, inhibiting Multidrug and toxin extrusion protein 1 (MATE1) with an IC 50 value of 19.24μM.

INK 128 (MLN0128) (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.

PIKfyve inhibitor,potent and selective

NU7441 (KU-57788) is a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC 50 of 13nM. NU7441 also inhibits phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with IC 50 of 5.0 and 1.7μM, respectively.

A-674563 is an orally active Akt inhibitor (K i =11nM).

MELK inhibitor,highly potent and selective

CHIR-98014 is a potent, cell-permeable inhibitor of GSK-3α and GSK-3β with IC 50 values of 0.65nM and 0.58nM, respectively.

PDK1 inhibitor,highly specific and potent

DNPK inhibitor,ATP-competitive and potent

Dorsomorphin (Compound C) 2HCl is a potent, cell-permeable dual inhibitor of AMPK and BMP pathways (K i value of 109nM for AMPK).

PI3K/Akt/mTOR inhibitor

RSK2 inhibitor

AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.

PI3Kγ/PI4KIIIβ/PI3Kα inhibitor

P90 RSK inhibitor,ATP-competitive and cell-permeable