GLPBio

Progesterone Receptor

Read More about this category

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Products Related to Progesterone Receptor(37)

  • GC10017 structure
    GC10017Gestodene
    CAS: 60282-87-3
    Purity: >99.50%

    Progestogen hormonal contraceptive

  • GC10215 structure
    GC10215Norethindrone
    CAS: 68-22-4
    Purity: >99.50%

    synthetic progestin

  • GC11144 structure
    GC11144Chlormadinone acetate
    CAS: 302-22-7
    Purity: >98.00%

    steroidal progestin with additional antiandrogen and antigonadotropic effects

  • GC11637 structure
    GC11637Mifepristone
    CAS: 84371-65-3
    Purity: >98.00%

    Mifepristone (RU486) is an orally effective progesterone (PR) receptor and glucocorticoid receptor (GR) antagonist used as an abortion drug with in vitro IC 50 values of 0.2nM and 2.6nM, respectively .

  • GC11677 structure
    GC11677Ulipristal acetate
    CAS: 126784-99-4
    Purity: >99.50%

    Novel selective progesterone receptor modulator (SPRM)

  • GC11688 structure
    GC11688Megestrol Acetate
    CAS: 595-33-5
    Purity: >99.50%

    Anti-estrogen agent

  • GC11964 structure
    GC11964Desogestrel
    CAS: 54024-22-5
    Purity: >99.50%

    progestin used in hormonal contraceptives

  • GC12000 structure
    GC12000Ethynodiol diacetate
    CAS: 297-76-7
    Purity: >99.00%

    Progestogen receptor agonist

  • GC12379 structure
    GC12379Drospirenone
    CAS: 67392-87-4
    Purity: >98.00%

    Synthetic progestin

  • GC12408 structure
    GC12408Progesterone
    CAS: 57-83-0
    Purity: >98.00%

    Progesterone

  • GC12974 structure
    GC12974Medroxyprogesterone acetate
    CAS: 71-58-9
    Purity: >99.50%

    Medroxyprogesterone acetate (MPA) is a synthetic progestin.

  • GC13297 structure
    GC13297Altrenogest
    CAS: 850-52-2
    Purity: >99.50%

    Progestogen receptor agonist

  • GC15409 structure
    GC15409Dydrogesterone
    CAS: 152-62-5
    Purity: >98.00%

    Potent, orally active progestogen

  • GC15578 structure
    GC15578Dienogest
    CAS: 65928-58-7
    Purity: >98.00%

    Orally active synthetic progesterone

  • GC16847 structure
    GC16847Tanaproget
    CAS: 304853-42-7
    Purity: >99.50%
  • GC17200 structure
    GC17200Nestoron
    CAS: 7759-35-5
    Purity: >99.50%

    A synthetic progestin

  • GC17305 structure
    GC17305Ulipristal
    CAS: 159811-51-5
    Purity: >98.00%

    progestogen receptor modulator

  • GC34200 structure
    GC34200Gestonorone Capronate
    CAS: 1253-28-7
    Purity: >98%

    Gestonorone Capronate is a progestin for the treatment of benign prostatic hypertrophy and endometrial cancer.

  • GC35408 structure
    GC35408Asoprisnil
    CAS: 199396-76-4
    Purity: >98.00%

    Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human.

  • GC36755 structure
    GC36755Nomegestrol acetate
    CAS: 58652-20-3
    Purity: >98.50%

    Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist.

  • GC36759 structure
    GC36759Norethindrone acetate
    CAS: 51-98-9
    Purity: >99.00%

    Norethindrone acetate is a female hormone used for the research of endometriosis.

  • GC38648 structure
    GC38648Cridanimod
    CAS: 38609-97-1
    Purity: >99.50%

    Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression.

  • GC39654 structure
    GC39654Norethisterone enanthate
    CAS: 3836-23-5
    Purity: >98.00%

    Norethisterone enanthate is a long-acting parenteral progestogen.

  • GC41153 structure
    GC41153Tibolone
    CAS: 5630-53-5
    Purity: >98.00%

    Tibolone is a synthetic steroid that possesses weak estrogenic, progestational and androgenic properties.