Phosphatase

PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM.

TD52 dihydrochloride, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity.

BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor.

ARL67156 (FPL 67156) trisodium hydrate is a selective ecto-ATPase inhibitor.

ARL67156 (FPL 67156) triethylamine is a selective ecto-ATPase inhibitor.

Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase.

EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells).

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 ?M.

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM.

SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM.

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).

EWP 815 is a disulfide analogue and an effective inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. It also participates in inhibiting the activity of dopamine beta-hydroxylase in vivo.

HKB99 is a conformational inhibitor of phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme. HKB99 inhibits the formation of invasive pseudopodia and increases the level of plasminogen activator inhibitor-2 (PAI-2). It also increases oxidative stress, activates JNK/c-Jun, and inhibits AKT and ERK. HKB99 can be used for research on non-small cell lung cancer (NSCLC).

JMS-053 is an effective, selective, and reversible inhibitor of PTP4A. It inhibits PTP4A1, PTP4A2, PTP4A3, CDC25B and DUSP3 with IC50 values of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM and 207.6 nM respectively. JMS-053 can inhibit cancer cell migration and spheroid growth while reducing the growth of ovarian tumors in vivo.

JUN-1111 is an irreversible selective inhibitor of Cdc25 phosphatase, with IC50 values of 0.38, 1.8, 0.66, 28 and 37 μM for Cdc25A, Cdc25B, Cdc25C, VHR and PTP1B respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases and reduces the expression of phosphoCdk1.

MY33-3 is an effective and selective inhibitor of protein tyrosine phosphatase RPTPβ/ζ, with an IC50 value of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate neuroinflammation and cognitive dysfunction caused by Sevoflurane.

PRL-3 Inhibitor 2 (compound 2) is an effective inhibitor of PRL-3, with an IC50 value of 28.1 μM.

SPAA-52 is a low molecular weight protein tyrosine phosphatase (LMW-PTP) inhibitor with oral activity, competitive and reversible properties (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used for research on diabetes.

Uralenol is a natural PTP1B inhibitor (IC50=21.5 μM) derived from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B has been shown to play a major role in the dephosphorylation of insulin receptors.

ML 400 is a potent and selective LMPTP inhibitor with an IC50 value of 1680 nM.

KLH45b is an inhibitor of DDHD2 (DDHD domain containing 2).