GLPBio

PS432

Catalog No.: GC72880Purity:>99.00%
COASDSData Sheet
PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively.

Products are for research use only. Not for human use. We do not sell to patients.

PS432
Cas No.: 2083630-26-4
1 mgIn Stock
$113.00
1
5 mgIn Stock
$342.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models.

PS432 (25 μM; 24 h) inhibits cancer cells proliferation, with IC50s of 30.7 μM (A549) and 12.4 μM (A427) in semi solid agar medium, for example[1].PS432 (50 μM; 12, 24, and 36 h) arrests cell cycle at G0/G1 phase in A549 lung cancer cells[1].

PS432 (2.5 mg/kg; i.p.; once daily for 14 d) inhibits tumor growth in xenograft model of lung cancer[1].

References:
[1]. Arencibia JM, et al. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem Biol. 2017 Feb 17;12(2):564-573.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2083630-26-4
Molecular Formula
C25H19ClN2O5S
Molecular Weight
494.95
Solubility
DMSO : 100 mg/mL (202.04 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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