PSB CB5 (Synonyms: CID-85469571) |
Catalog No.GC50435 |
Selective GPR18 antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1627710-30-8
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine induced acrosomal exocytosis in human spermatozoa.
Rempel et al (2014) Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm. 5 632 |Flegel et al (2016) Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 6 32255 PMID:27572937
Cas No. | 1627710-30-8 | SDF | |
Synonyms | CID-85469571 | ||
Chemical Name | (2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one | ||
Canonical SMILES | O=C(N1C(SCCC1)=N/2)C2=C\C3=CC(OCC4=CC=C(Cl)C=C4)=CC=C3 | ||
Formula | C20H17ClN2O2S | M.Wt | 384.88 |
Solubility | 7.7mg/ml in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.5982 mL | 12.9911 mL | 25.9821 mL |
5 mM | 0.5196 mL | 2.5982 mL | 5.1964 mL |
10 mM | 0.2598 mL | 1.2991 mL | 2.5982 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 28 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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