Pulmonary Diseases

11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.

Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 ug/ml.

16,16-dimethyl PGF2β is a metabolically stable analog of PGF2β.

Sivelestat sodium tetrahydrate is a specific inhibitor of neutrophil elastase with an IC 50 value of 14nM.

(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.

Beta-Sitosterol is a plant sterol with multiple biological activities, including anti-inflammatory, anti-tumor, antipyretic and immunomodulatory activities.

An acetate form of dexamethasone

An AT 2 receptor agonist

Dihydroresveratrol is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota.

15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO.

15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO.

2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.

(±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst.

Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst.

(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.

Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis.

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.

Sappanone A is a homoisoflavanone with strong antioxidant and anti-inflammatory activities.

3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.

Salbutamol (albuterol) is a selective β2-adrenergic partial agonist that is used as a bronchodilator.

Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G.

BMS 470539 (hydrochloride) is a highly selective and potent melanocortin-1 receptor (MC-1R) agonist. In cAMP accumulation assays, its EC 50 values for human and mouse MC1R are 16.8 and 11.6nM, respectively.

C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.