RAD51
RAD51 is a protein that contributed to homologous recombination and DSB (DNA double-strand break) repair in the DNA damage response pathway. It is associated with genome instablility and tumorgenesis.
Products Related to RAD51(13)
- GC19306RAD51 Inhibitor B02CAS: 1290541-46-6Purity: >99.50%
RAD51 Inhibitor B02 is a specific inhibitor of the human RAD51 recombinase (with an IC 50 value of 27.4μM), and it has no inhibitory effect on the homologous RecA in Escherichia coli (with an IC 50 > 250μM).
- GC33362Amuvatinib hydrochloride (MP470 hydrochloride)CAS: 1055986-67-8Purity: >98%
Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity.
- GC62128BractoppinCAS: 2290527-07-8Purity: >99.00%
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain with an IC 50 value of 74nM.
- GC63165RAD51-IN-1CAS: 2101739-18-6Purity: >99.50%
RAD51-IN-1, a derivative of ?B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research.
- GC65383RAD51-IN-2CAS: 2301085-04-9Purity: >99.00%
RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC12752 | RI-2 | 1417162-36-7 | >99.50% | |
Optimized reversible RAD51 inhibitor | ||||
| GC16265 | RS-1 | 312756-74-4 | >98.50% | |
RAD51 activator | ||||
| GC16391 | Amuvatinib (MP-470, HPK 56) | 850879-09-3 | >98.00% | |
A multi-targeted RTK inhibitor | ||||
| GC18140 | RI-1 | 415713-60-9 | >99.50% | |
RI-1 is a RAD51 protein inhibitor, with IC 50 values ranging from 5 to 30μM. | ||||
| GC19306 | RAD51 Inhibitor B02 | 1290541-46-6 | >99.50% | |
RAD51 Inhibitor B02 is a specific inhibitor of the human RAD51 recombinase (with an IC 50 value of 27.4μM), and it has no inhibitory effect on the homologous RecA in Escherichia coli (with an IC 50 > 250μM). | ||||
| GC32912 | IBR2 | 313526-24-8 | >97.00% | |
IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis. | ||||
| GC33362 | Amuvatinib hydrochloride (MP470 hydrochloride) | 1055986-67-8 | >98% | |
Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity. | ||||
| GC62128 | Bractoppin | 2290527-07-8 | >99.00% | |
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain with an IC 50 value of 74nM. | ||||
| GC63165 | RAD51-IN-1 | 2101739-18-6 | >99.50% | |
RAD51-IN-1, a derivative of ?B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research. | ||||
| GC65383 | RAD51-IN-2 | 2301085-04-9 | >99.00% | |
RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1. | ||||
| GC65935 | CAM833 | 2758364-02-0 | >98.00% | |
CAM833, a sub-micromolar chemical inhibitor of the regulatory protein-protein interaction between the RAD51 recombinase and the BRC repeat motifs of the tumor suppressor BRCA2. | ||||
| GC67888 | RAD51-IN-5 | 2690367-19-0 | >98% | |
| GC68416 | RAD51-IN-3 | 2301084-99-9 | >99.00% | |