Cyclin-Dependent Kinases
Cyclin-dependent kinases is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.
Products Related to Cyclin-Dependent Kinases(70)
- GC16429(R)-DRF053 dihydrochlorideCAS: 1241675-76-2Purity: >98%
cdk/CK1 inhibitor,potent and ATP-competitive
- GC17935PD 0332991 (Palbociclib) HClCAS: 827022-32-2Purity: >99.00%
PD 0332991, as an orally active potent and highly selective inhibitor of CDK4 and CDK6 kinases, can block pRb phosphorylation and subsequently inducing G1 arrest in sensitive cell lines in low nanomolar concentrations.
- GC18051CCT251545 analogue, Compound 51Purity: >98%
Potent, Selective, orally bioavailable CDK 8/19 Inhibitor
- GC15377LEE011 succinateCAS: 1374639-75-4Purity: >99.50%
LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
- GC15922LEE011 hydrochlorideCAS: 1211443-80-9Purity: >98.00%
LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC16429 | (R)-DRF053 dihydrochloride | 1241675-76-2 | >98% | |
cdk/CK1 inhibitor,potent and ATP-competitive | ||||
| GC16520 | Olomoucine | 101622-51-9 | >99.50% | |
cdk inhibitor | ||||
| GC16545 | GX-674 | 1432913-36-4 | >98% | |
GX-674 is an aryl sulfonamide class of antagonist that inhibits Nav1.7 channel with an IC 50 value of 0.1nM. | ||||
| GC16822 | LY2835219 | 1231930-82-7 | >99.00% | |
LY2835219 (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively. | ||||
| GC16959 | NVP-LCQ195 | 902156-99-4 | >99.50% | |
| GC17150 | Ryuvidine | 265312-55-8 | >95.00% | |
Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC 50 value of 0.5μM. | ||||
| GC17359 | CDK9 inhibitor 2 | 1263369-28-3 | >99.50% | |
| GC17792 | SCH900776 S-isomer | 891494-64-7 | >98.50% | |
| GC17935 | PD 0332991 (Palbociclib) HCl | 827022-32-2 | >99.00% | |
PD 0332991, as an orally active potent and highly selective inhibitor of CDK4 and CDK6 kinases, can block pRb phosphorylation and subsequently inducing G1 arrest in sensitive cell lines in low nanomolar concentrations. | ||||
| GC18028 | CVT-313 | 199986-75-9 | >99.50% | |
A Cdk2 inhibitor | ||||
| GC18051 | CCT251545 analogue, Compound 51 | - | >98% | |
Potent, Selective, orally bioavailable CDK 8/19 Inhibitor | ||||
| GC50175 | CGP 74514 dihydrochloride | - | >98% | |
Potent cdk1 inhibitor | ||||
| GC15963 | Nu 6027 | 220036-08-8 | >99.00% | |
ATR/CDK inhibitor, potent and selective | ||||
| GC14162 | ML167 | 1285702-20-6 | >98.50% | |
Clk4 inhibitor,highly selective | ||||
| GC14974 | AMG 925 | 1401033-86-0 | >98.00% | |
AMG 925 is an orally active dual FLT3 and CDK4 kinase inhibitor (IC 50 =1nM and 3nM). | ||||
| GC15377 | LEE011 succinate | 1374639-75-4 | >99.50% | |
LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. | ||||
| GC15922 | LEE011 hydrochloride | 1211443-80-9 | >98.00% | |
LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. | ||||
| GC16000 | WHI-P180 | 211555-08-7 | >99.50% | |
EGFR/Janus Kinase 3 inhibitor | ||||
| GC17067 | LDC000067 | 1073485-20-7 | >98.50% | |
CDK9 inhibitor, novel and highly specific | ||||
| GC17400 | R547 | 741713-40-6 | >99.50% | |
CDK1/2/4 inhibitor,ATP-competitive | ||||
| GC12642 | THZ1 Hydrochloride | 1604810-83-4 | >98.00% | |
CDK7 inhibitor | ||||
| GC15914 | CDK7-IN-1 | 1604810-84-5 | - | |
potent and selective CDK7 inhibitor | ||||