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CDK

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<div class="colum_1 clearer"><p>CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.</p><p>There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.</p><p>CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of <i>S. pombe</i> (Cdc2), <i>S. cerevisia</i> (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).</p></div>

Products Related to CDK(299)

  • GC73264 structure
    GC73264Multi-target kinase inhibitor 2
    Purity: >99.00%

    Multi-target kinase inhibitor 2 (compound 5K) is a multi-targeted kinase inhibitor, and exhibits activity against EGFR, Her2, VEGFR2, and CDK2 enzymes, with IC50 values ranging from 40 to 204 nM.

  • GC73270 structure
    GC73270XPW1
    CAS: 2700286-66-2
    Purity: >99.00%

    XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity.

  • GC73286 structure
    GC73286PROTAC CDK9 degrader-7
    CAS: 2935587-90-7
    Purity: >99.00%

    PROTAC CDK9 degrader-7 is a PROTAC targeting to CDK9 sepcifically.

  • GC73288 structure
    GC73288CDK8-IN-13
    CAS: 918523-75-8
    Purity: >98.00%

    CDK8-IN-13 is a potent, selective, and orally active CDK8 inhibitor with an IC 50 value of 51.9nM.

  • GC73345 structure
    GC73345CDK8-IN-11
    CAS: 2839338-28-0
    Purity: >98.00%

    CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC50 value of 46 nM.

  • GC73426 structure
    GC73426MFH290
    CAS: 2088715-91-5
    Purity: >98.00%

    MFH290 is a potent and highly selective cyclin-dependent kinase 12/13 (CDK12/13) covalent inhibitor.

  • GC73429 structure
    GC73429CDK7-IN-21
    CAS: 2766124-39-2
    Purity: >96.00%

    CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor.

  • GC73504 structure
    GC73504SRX3177
    CAS: 2241237-51-2
    Purity: >99.00%

    SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively.

  • GC73590 structure
    GC73590MAPK-IN-2
    Purity: >98.00%

    MAPK-IN-2 (compound 3h) is a potent MAPK inhibitor with antineoplastic activity.

  • GC73597 structure
    GC73597ZNL-05-044
    Purity: >99.00%

    ZNL-05-044 is a CDK11 inhibitor with an IC50s of 0.23 μM and 0.27 μM against CDK11A and CDK11B, respectively (NanoBRET assay).

  • GC73758 structure
    GC73758Ribociclib-d8
    CAS: 2167898-24-8
    Purity: >99.00%

    Ribociclib-d8 is the deuterium labeled Ribociclib.

  • GC73787 structure
    GC73787AZD8421
    CAS: 3047321-53-6
    Purity: >98.00%

    AZD8421 is a selective CDK2 inhibitor (IC50: 9 nM) with selectivity for CDK1, CDK4 and CDK6.

  • GC73880 structure
    GC73880DS17
    Purity: >98.00%

    DS17 is a molecular glue that acts as a potent degrader of cyclin K, with an EC50 of 13 nM.

  • GC73893 structure
    GC73893BLU-222
    CAS: 2888704-84-3
    Purity: >98.00%

    BLU-222 is an orally active and highly selective CDK2 inhibitor.

  • GC73934 structure
    GC73934Cyclin K degrader 1
    Purity: >99.00%

    Cyclin K degrader 1 (compound 40) is an AT7519 based Cyclin K degrader with DC50 of 21 nM.

  • GC73965 structure
    GC73965INX-315
    CAS: 2745060-92-6
    Purity: >99.00%

    INX-315 is an orally active and selective CDK2 inhibitor that induces cell cycle arrest in the G1 phase.

  • GC73970 structure
    GC73970CDDD11-8
    CAS: 2241659-94-7
    Purity: >99.00%

    CDDD11-8 is an orally active, potent and selective inhibitor of CDK9 and FLT3-ITD, with Ki values of 8 and 13 nM, respectively.

  • GC73976 structure
    GC73976CDK2-IN-23
    CAS: 2488073-20-5
    Purity: >99.00%

    CDK2-IN-23 (Compound 17) is a kinase selective and highly potent CDK2 inhibitor (IC50 = 0.29 nM).

  • GC74050 structure
    GC74050PROTAC CDK4/6 degrader 1
    CAS: 3025082-14-5
    Purity: >98.00%

    PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM.

  • GC74161 structure
    GC74161Palbociclib hydrochloride
    CAS: 571189-11-2
    Purity: >99.50%

    Palbociclib (PD 0332991) drochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively.

  • GC74261 structure
    GC74261(R)-(+)-O-Demethylbuchenavianine
    CAS: 1364123-68-1
    Purity: >98.00%

    (R)-(+)-O-Demetlbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK).

  • GC74262 structure
    GC74262(S)-(-)-O-Demethylbuchenavianine
    CAS: 91147-18-1

    (S)-(-)-O-Demetlbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids.

  • GC74324 structure
    GC74324Cdk5i peptide
    CAS: 2298317-00-5
    Purity: >99.00%

    Cdk5i peptide is a 12-amino acid peptide fragment derived from Cdk5.

  • GC74727 structure
    GC74727JSH-009
    CAS: 2247481-08-7

    JSH-009 is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation.