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CDK

<div class="colum_1 clearer"><p>CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.</p><p>There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.</p><p>CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of <i>S. pombe</i> (Cdc2), <i>S. cerevisia</i> (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).</p></div>

Targets for  CDK

Products for  CDK

  1. Cat.No. Product Name Information
  2. GC33107 (±)-BAY-1251152 (±)-BAY-1251152  Chemical Structure
  3. GC32429 (-)-BAY-1251152 (-)-BAY-1251152  Chemical Structure
  4. GC38377 (2S,3R)-Voruciclib hydrochloride (2S,3R)-Voruciclib hydrochloride  Chemical Structure
  5. GC63864 (E/Z)-Zotiraciclib hydrochloride (E/Z)-Zotiraciclib hydrochloride  Chemical Structure
  6. GC41716 (R)-CR8 Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-CR8  Chemical Structure
  7. GC39281 (R)-CR8 trihydrochloride (R)-CR8 trihydrochloride  Chemical Structure
  8. GC34124 (rel)-MC180295 (rel)-MC180295  Chemical Structure
  9. GC60532 6-(Dimethylamino)purine 6-(Dimethylamino)purine  Chemical Structure
  10. GC63728 Abemaciclib metabolite M18 hydrochloride Abemaciclib metabolite M18 hydrochloride  Chemical Structure
  11. GC38749 Abemaciclib metabolite M20 Abemaciclib metabolite M20  Chemical Structure
  12. GC35218 Abemaciclib Metabolites M2 Abemaciclib Metabolites M2  Chemical Structure
  13. GC64280 Abemaciclib-d8 Abemaciclib-d8  Chemical Structure
  14. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone  Chemical Structure
  15. GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective AMG 925  Chemical Structure
  16. GC35315 AMG 925 HCl AMG 925 HCl  Chemical Structure
  17. GC63375 AS-0141 AS-0141  Chemical Structure
  18. GC38736 AS2863619 AS2863619  Chemical Structure
  19. GC38737 AS2863619 free base AS2863619 free base  Chemical Structure
  20. GC15870 AT7519 Multi-CDK inhibitor AT7519  Chemical Structure
  21. GC13998 AT7519 Hydrochloride Multi-CDK inhibitor AT7519 Hydrochloride  Chemical Structure
  22. GC15597 AT7519 trifluoroacetate CDK/cyclin inhibitor AT7519 trifluoroacetate  Chemical Structure
  23. GC34422 Atuveciclib (BAY-1143572) Atuveciclib (BAY-1143572)  Chemical Structure
  24. GC34059 Atuveciclib Racemate (BAY-1143572 Racemate) Atuveciclib Racemate (BAY-1143572 Racemate)  Chemical Structure
  25. GC34421 Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer)  Chemical Structure
  26. GC63449 Avotaciclib Avotaciclib  Chemical Structure
  27. GC12438 AZD-5438 Potent CDK1/2/9 inhibitor AZD-5438  Chemical Structure
  28. GC32717 AZD4573 AZD4573  Chemical Structure
  29. GC19067 BGG463 BGG463 is a CDK2 inhibitor. BGG463  Chemical Structure
  30. GC35512 BI-1347 BI-1347  Chemical Structure
  31. GC62653 bio-THZ1 bio-THZ1  Chemical Structure
  32. GC18354 Bisindolylmaleimide X (hydrochloride) Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). Bisindolylmaleimide X (hydrochloride)  Chemical Structure
  33. GC12865 BMS265246 CDK1/2 inhibitor,potent and selective BMS265246  Chemical Structure
  34. GC11040 Borrelidin threonyl-tRNA synthetase (ThrRS) inhibitor Borrelidin  Chemical Structure
  35. GC50452 BRD 6989 Cdk8 inhibitor; enhances IL-10 production BRD 6989  Chemical Structure
  36. GC50217 BS 181 dihydrochloride Selective cdk7 inhibitor BS 181 dihydrochloride  Chemical Structure
  37. GC12001 BS-181 CDK7 inhibitor,highly selective BS-181  Chemical Structure
  38. GC13690 BS-181 HCl CDK7 inhibitor,highly selective BS-181 HCl  Chemical Structure
  39. GC50615 BSJ-03-204 Selective Cdk4/6 degrader BSJ-03-204  Chemical Structure
  40. GC62263 BSJ-4-116 BSJ-4-116  Chemical Structure
  41. GC30977 Ca2+ channel agonist 1 Ca2+ channel agonist 1  Chemical Structure
  42. GC62442 Casein Kinase inhibitor A51 Casein Kinase inhibitor A51  Chemical Structure
  43. GC43175 CAY10574 Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. CAY10574  Chemical Structure
  44. GC19089 CC-671 CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC50s of 0.005 and 0.006 uM for TTK and CLK2, respectively. CC-671  Chemical Structure
  45. GC32741 CCT-251921 CCT-251921  Chemical Structure
  46. GC62427 Cdc7-IN-5 Cdc7-IN-5  Chemical Structure
  47. GC12425 CDK inhibitor II CDK inhibitor CDK inhibitor II  Chemical Structure
  48. GC38899 CDK ligand for PROTAC hydrochloride CDK ligand for PROTAC hydrochloride  Chemical Structure
  49. GC62168 CDK-IN-6 CDK-IN-6  Chemical Structure
  50. GC63499 CDK12-IN-2 CDK12-IN-2  Chemical Structure
  51. GC35633 CDK4/6-IN-2 CDK4/6-IN-2  Chemical Structure
  52. GC60680 CDK5 inhibitor 20-223 CDK5 inhibitor 20-223  Chemical Structure
  53. GC63980 CDK7-IN-2 CDK7-IN-2  Chemical Structure
  54. GC62596 CDK7-IN-3 CDK7-IN-3  Chemical Structure
  55. GC60681 CDK7/9 tide CDK7/9 tide  Chemical Structure
  56. GC33180 CDK8-IN-1 CDK8-IN-1  Chemical Structure
  57. GC30466 CDK8-IN-3 CDK8-IN-3  Chemical Structure
  58. GC33366 CDK8-IN-4 CDK8-IN-4  Chemical Structure
  59. GC12871 CDK9 inhibitor CDK9 inhibitor CDK9 inhibitor  Chemical Structure
  60. GC17359 CDK9 inhibitor 2 CDK9 inhibitor CDK9 inhibitor 2  Chemical Structure
  61. GC19096 CDKI-73 CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). CDKI-73  Chemical Structure
  62. GC63476 Cirtuvivint Cirtuvivint  Chemical Structure
  63. GC63800 CK7 CK7  Chemical Structure
  64. GC38755 CKI-7 CKI-7  Chemical Structure
  65. GC30245 CLK1-IN-1 CLK1-IN-1  Chemical Structure
  66. GC33327 CMPD 7 CMPD 7  Chemical Structure
  67. GC32735 CT7001 hydrochloride (ICEC0942 hydrochloride) CT7001 hydrochloride (ICEC0942 hydrochloride)  Chemical Structure
  68. GN10526 Cucurbitacin E inhibits actin depolymerization Cucurbitacin E  Chemical Structure
  69. GC18028 CVT-313 Cdk2 inhibitor CVT-313  Chemical Structure
  70. GC32700 CYC065 CYC065  Chemical Structure
  71. GC63419 Dalpiciclib Dalpiciclib  Chemical Structure
  72. GC38482 Desmethylglycitein Desmethylglycitein  Chemical Structure
  73. GC17648 Dinaciclib(SCH727965) Potent CDK inhibitor Dinaciclib(SCH727965)  Chemical Structure
  74. GC38330 EHT 5372 EHT 5372  Chemical Structure
  75. GC16063 Flavopiridol Pan-cdk inhibitor Flavopiridol  Chemical Structure
  76. GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective Flavopiridol hydrochloride  Chemical Structure
  77. GC36062 FMF-04-159-2 FMF-04-159-2  Chemical Structure
  78. GC50719 FMF-04-159-R FMF-04-159-R  Chemical Structure
  79. GC33049 FN-1501 FN-1501  Chemical Structure
  80. GN10696 Garcinone C Extracted from Garcinia mangostana;Store the product in sealed, cool and dry condition Garcinone C  Chemical Structure
  81. GC14987 GSK-3 Inhibitor IX (BIO) GSK-3α/GSK-3β inhibitor, cell-permeable and ATP-competitive GSK-3 Inhibitor IX (BIO)  Chemical Structure
  82. GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1  Chemical Structure
  83. GC63854 HQ461 HQ461  Chemical Structure
  84. GC62572 hSMG-1 inhibitor 11e hSMG-1 inhibitor 11e  Chemical Structure
  85. GC61925 hSMG-1 inhibitor 11j hSMG-1 inhibitor 11j  Chemical Structure
  86. GC63023 Ipivivint Ipivivint  Chemical Structure
  87. GC63460 IV-361 IV-361  Chemical Structure
  88. GC12612 JNJ-7706621

    Potent CDK/Aurora kinase inhibitor

    JNJ-7706621  Chemical Structure
  89. GC34204 JSH-150 JSH-150  Chemical Structure
  90. GC14230 K03861 CDK2 inhibitor K03861  Chemical Structure
  91. GC62392 KB-0742 dihydrochloride KB-0742 dihydrochloride  Chemical Structure
  92. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone  Chemical Structure
  93. GC11774 KH CB19 inhibitor of CLK1 and CLK4, potent and selective KH CB19  Chemical Structure
  94. GC63943 KH-CB20 KH-CB20  Chemical Structure
  95. GC50532 KuWal151 Potent and selective CLK inhibitor KuWal151  Chemical Structure
  96. GC17067 LDC000067 CDK9 inhibitor, novel and highly specific LDC000067  Chemical Structure
  97. GC19219 LDC4297 LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. LDC4297  Chemical Structure
  98. GC10842 LEE011 CDK4/6 inhibitor LEE011  Chemical Structure
  99. GC15922 LEE011 hydrochloride CDK inhibitor LEE011 hydrochloride  Chemical Structure
  100. GC15377 LEE011 succinate CDK inhibitor LEE011 succinate  Chemical Structure
  101. GC34163 Lerociclib (G1T38) Lerociclib (G1T38)  Chemical Structure

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