Pim
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Pim protein kinases are a family of serine/threonine kinases consisting of three members of Ca2+/calmodulin-dependent protein kinases, including PIM1, PIM2 and PIM3, that are responsible for cell cycle regulation and antiapoptotic activity as well as homing and migration of receptor tyrosine kinases mediated through the JAK/STAT pathway. All three pim protein kinases share high homology at the amino acid level and hence exhibit greatly overlapping functions, in which 71% and 61% identical amino acids have been found between PIM1/PIM3 and between PIM1/PIM2 respectively. PIM1 comprises two isoforms of 34 and 44 kDa respectively; while PIM2 comprises three isoforms of 34, 37 and 40 kDa respectively. However, PIM3 comprises only one protein.
Products Related to Pim(35)
- GC49412NSC 756093CAS: 1629908-92-4Purity: >98.00%
An inhibitor of the GBP1-Pim-1 protein-protein interaction
- GC64774SEL24-B489CAS: 1616359-00-2Purity: >98.00%
SEL24-B489 is a potent, type I, orally active, dual PIM and FLT3-ITD inhibitor, with Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively.
- GC65278PIM1-IN-1CAS: 1417630-95-5Purity: >99.00%
PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity.
- GC72931HTH-01-091 TFAPurity: >98.00%
HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM.
- GC73968Pim-1 kinase inhibitor 8CAS: 916038-47-6Purity: >99.00%
Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC39485 | CK2/ERK8-IN-1 | 1085822-09-8 | >99.00% | |
A dual inhibitor of CK2 and ERK8 | ||||
| GC49412 | NSC 756093 | 1629908-92-4 | >98.00% | |
An inhibitor of the GBP1-Pim-1 protein-protein interaction | ||||
| GC64774 | SEL24-B489 | 1616359-00-2 | >98.00% | |
SEL24-B489 is a potent, type I, orally active, dual PIM and FLT3-ITD inhibitor, with Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively. | ||||
| GC65201 | Quercetagetin | 90-18-6 | >99.00% | |
Quercetagetin (6-Hydroxyquercetin) is a flavonoid. | ||||
| GC65278 | PIM1-IN-1 | 1417630-95-5 | >99.00% | |
PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity. | ||||
| GC72931 | HTH-01-091 TFA | - | >98.00% | |
HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. | ||||
| GC72990 | HJ-PI01 | 6192-43-4 | >99.00% | |
HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. | ||||
| GC73729 | IBL-302 | 1414455-21-2 | >98.00% | |
IBL-302 (AMU302) is an orally available dual-signaling inhibitor of PIM and PI3K/AKT/mTOR with activity against breast cancer and neuroblastoma. | ||||
| GC73968 | Pim-1 kinase inhibitor 8 | 916038-47-6 | >99.00% | |
Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. | ||||
| GC79451 | JP-11646 | 1902983-63-4 | >98.50% | |
JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM). | ||||
| GC79477 | KZ-02 | 1801756-14-8 | >98.00% | |
KZ-02 is an orally active dual MEK1 / Pim-1 kinase inhibitor, with an IC 50 of 1.07 nM against MEK1 and an IC 50 of 1.34 μM against Pim-1. | ||||