GLPBio

Melanocortin (MC) Receptors

Read More about this category

Melanocortin receptors (MCRs) comprise a family of five, class A, G protein-coupled receptors designated MC1R-MC5R with diverse physiological roles. MCRs are found in chordates and are regarded as having evolved from a single ancestral receptor, possibly corresponding most closely to MC4R. Signaling by MCRs has primarily been observed as occurring through the stimulatory α unit Gs which activates adenylyl cyclase to produce cAMP.

The central nervous melanocortin system is involved in energy homeostasis, regulating food intake and energy expenditure. The brain melanocortin system is defined as the primary neurons that express neuropeptide ligands, and secondary neurons expressing the predominant neural melanocortin receptors (MC3R, MC4R). Mutations in the gene encoding melanocortin receptor agonists, or the genes encoding MC3R or MC4R cause obesity. The other members of the melanocortin receptor family are primarily expressed in the periphery, and are involved in regulating pigmentation (MC1R), adrenal gland function (MC2R), immune function (MC1R/MC3R), and sebaceous gland activity (MC5R).

Products Related to Melanocortin (MC) Receptors(57)

  • GC34002 structure
    GC34002Bremelanotide Acetate (PT-141 Acetate)
    CAS: 1607799-13-2
    Purity: >99.00%

    Bremelanotide Acetate (PT-141 Acetate) (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction.

  • GC35244 structure
    GC35244ACTH (1-17) TFA
    Purity: >99.00%
  • GC35254 structure
    GC35254Adrenocorticotropic Hormone (ACTH) (1-39), rat
    CAS: 77465-10-2
    Purity: >98%

    Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist.

  • GC35255 structure
    GC35255Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA
    Purity: >99.50%

    Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 (MC2) receptor agonist.

  • GC36727 structure
    GC36727Neuropeptide EI, rat
    CAS: 125934-45-4
    Purity: >98%

    Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.

  • GC36756 structure
    GC36756Nonapeptide-1 acetate salt
    Purity: >99.50%

    Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM).

  • GC37629 structure
    GC37629Setmelanotide TFA
    Purity: >98%
  • GC38007 structure
    GC38007β-Melanocyte Stimulating Hormone (MSH), human TFA
    Purity: >99.50%
  • GC38107 structure
    GC38107SNT-207858 free base
    CAS: 1104662-66-9
    Purity: >98.00%

    SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist.

  • GC50303 structure
    GC50303MSG 606
    CAS: 1416983-77-1
    Purity: >98%

    MSG-606 has potent antagonist activity and receptor selectivity for the human melanocortin 1 receptor (hMC1R) (IC50 = 17 nM) .

  • GC63724 structure
    GC63724HS014 TFA
    Purity: >98.50%

    HS014 TFA is a potent and selective melanocortin MC4 receptor antagonist (K i =3.16nM).

  • GC63756 structure
    GC63756PG106 TFA
    Purity: >99.00%

    PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50= 210 nM) and has noactivity at?hMC4?receptors (EC50=9900 nM) and?hMC5?receptor.

  • GC63770 structure
    GC63770HS024 TFA
    Purity: >99.50%

    HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively.

  • GC64427 structure
    GC64427MK-0493
    CAS: 455956-93-1
    Purity: >98%

    MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

  • GC64525 structure
    GC64525Fenoprofen
    CAS: 29679-58-1
    Purity: >99.00%

    Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID).

  • GC66383 structure
    GC66383ACTH (11-24) (acetate)
    Purity: >98.00%

    ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.

  • GC68965 structure
    GC68965Dersimelagon
    CAS: 1835256-48-8
    Purity: >97.00%

    Dersimelagon (MT-7117) is a selective melanocortin 1 receptor (MC1R) agonist with oral activity. Its EC50 values for human (h), crab-eating macaque (cm), mouse (m), and rat (r) MC1R are 8.16, 3.91, 1.14, and 0.251 nM respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26 and 32.9 nM respectively. It can be used in research on skin pigmentation [1][2].

  • GC69472 structure
    GC69472ML00253764
    CAS: 681847-92-7
    Purity: >99.00%

    ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist that induces apoptosis by inhibiting ERK1/2 and Akt phosphorylation, exhibiting anticancer activity.

  • GC69813 structure
    GC69813Resomelagon
    CAS: 1809420-71-0
    Purity: >98%

    Resomelagon (AP1189) is an orally effective melanocortin receptor (MR) agonist, including MC1 and MC3. Resomelagon induces phosphorylation of ERK1/2 and Ca2+ flow. Resomelagon has anti-inflammatory activity. Resomelagon can be used for obesity and chronic inflammation research.

  • GC69814 structure
    GC69814Resomelagon acetate
    CAS: 1809420-72-1
    Purity: >98%

    Resomelagon (AP1189) acetate is an orally effective melanocortin receptor (MR) agonist, including MC1 and MC3. Resomelagon acetate induces ERK1/2 phosphorylation and Ca2+ flux. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research.

  • GC71028 structure
    GC71028PF-07258669
    CAS: 2755890-53-8
    Purity: >98.00%

    PF-07258669 is a melanocortin-4 receptor (MC4) antagonist.

  • GC71439 structure
    GC71439CRN04894
    CAS: 2392970-97-5

    CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion.

  • GC72123 structure
    GC72123β-Melanocyte Stimulating Hormone (MSH), human TFA
    Purity: >99.00%

    β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

  • GC72308 structure
    GC72308TCMCB07 TFA
    Purity: >99.00%

    TCMCB07 TFA, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist.