Autoimmunity

S1PL-IN-31 is an inhibitor of sphingosine-1-phosphate (S1P) lyase (IC50 = 210 nM).

PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.

BDW-OH is an active metabolite of the STING agonist and prodrug BDW568 .

PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity.

TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM).

NVS-STG2 is an agonist of stimulator of interferon genes (STING).

LB244 is an irreversible STING antagonist.

PDIC-NS is an activator of stimulator of interferon genes (STING).

Fenoprofen-13C6 is intended for use as an internal standard for the quantification of fenoprofen by GC- or LC-MS.

Napirimus is an immunosuppressant.

Fenclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 7 and 4 ?M for COX-1 and COX-2, respectively).

BH400 is an agonist of peroxisome proliferator-activated receptor α (PPARα) and an inhibitor of stimulator of interferon genes (STING; IC50 = 8.1 ?M).

PQA-18 is an inhibitor of p21-activated kinase 2 (PAK2; IC50 = 10 nM), an immunosuppressant, and a derivative of Ppc-1.