Fenclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 7 and 4 ?M for COX-1 and COX-2, respectively).1,2 It reduces paw volume in a rat model of adjuvant-induced polyarthritis when administered at doses of 3, 15, and 75 mg/kg and reverses yeast-induced motor impairments, a measure of nociception, in rats (ED50 = 54.3 mg/kg).1 Fenclofenac (20-180 mg/kg) reduces carrageenan-induced paw edema in rats. Formulations containing fenclofenac have previously been used in the treatment of rheumatoid arthritis.
References:
[1]. Atkinson, D.C., and Leach, E.C.Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)Agents Actions6(5)657-666(1976).
[2]. Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim. Biophys. Acta1209(1)130-139(1994).