IκB/IKK

TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR.

GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.

MLN120B dihydrochloride (ML120B dihydrochloride) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis.

(Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects.

TBK1-IN-1 is an effective selective inhibitor of TANK-binding kinase 1 (TBK1), with an IC50 value of 22.4 nM. TBK1-IN-1 inhibits the expression of downstream target genes cxcl10 and ifnβ of TBK1. TBK1-IN-1 has anti-cancer activity.

Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity.

SAR113945 monopotassium is a highly selective IKK-β inhibitor with an IC 50 value of 0.4 nM.

TBK1 ligand 3 is a TBK1 ligand, which can be used as a target protein ligand for the synthesis of PROTAC UNC8209 and UNC8461 [1] .

MLN-0415 is an IKKβ inhibitor.

Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60).

CDDO-biotin is an IKKβ inhibitor with cancer cell inhibitory activity.

Luteolin is a flavonoid compound with multiple functions such as anti-inflammatory, antioxidant, and anti-cancer. Luteolin is an effective inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2).

Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol.

Honokiol is a natural bisphenol chemical with multiple biological activities. It targets multiple signaling molecules and has effective antioxidant, anti-inflammatory, anti-angiogenic and anti-cancer activities. It also has broad-spectrum antibacterial and anti-human immunodeficiency virus (HIV) activities.

Tanshinone IIA is a major tanshinone isolated from Salvia divinorum. Commonly used in cardiovascular disease and cancer research.

Bay 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα with an IC 50 value of 10μM for IκBα.

ATP-competitive IKK-2 inhibitor, orally active