IκB/IKK
IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.
Products for IκB/IKK
- Cat.No. Product Name Information
- GC66334 (Rac)-PF-184 hydrate (Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects.
- GC17416 ACHP IκB kinase inhibitor
- GC31319 Amlexanox (AA673) Amlexanox (AA673) (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
- GN10718 Andrographolide
- GC10135 AZD3264 IKK2 inhibitor
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GC10345
Bay 11-7085
NK-κB activation inhibitor
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GC13035
Bay 11-7821
A selective and irreversible NF-κB inhibitor
- GC35474 Bay 65-1942 free base Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor.
- GC16303 Bay 65-1942 HCl salt
- GC35475 Bay 65-1942 R form Bay 65-1942 R form is the less active R-form of Bay 65-1942.
- GC60624 BAY-985 A dual inhibitor of TBK1 and IKKε
- GC18200 BI-605906 BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit β (IKKβ; IC50 = 380 nM).
- GC32028 BMS-066 BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively.
- GC13926 BMS-345541(free base) BMS-345541(free base) is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541(free base) binds at an allosteric site of IKK.
- GC12399 BMS345541 hydrochloride A selective inhibitor of IKKα and IKKβ
- GC15083 Celastrol A triterpenoid antioxidant
- GC35674 Chicanine Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity.
- GC11170 Choline Fenofibrate
- GC17873 CID-2858522 A selective inhibitor of NF-κB activation
- GC16044 Emodin Natural CK2 inhibitor and ER agonist
- GC33816 Ertiprotafib (PTP 112) Ertiprotafib (PTP 112) is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
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GC43786
GS-143
GS-143 is an inhibitor of IκBα ubiquitylation.
- GC65013 GSK8612 GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
- GC62161 HOIPIN-1 HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM. HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro.
- GN10664 Honokiol
- GC63007 HPN-01 HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively.
- GC12370 IKK-16 (hydrochloride) IκB kinases (IKKs) inhibitor
- GC12180 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.
- GC11508 IKK-2 inhibitor VIII
- GC10592 IKK-3 Inhibitor A multi-kinase inhibitor
- GC13278 IKKε-IN-1 potent IKKε inhibitor
- GC17830 IMD 0354 IKKβ inhibitor
- GC33306 IMD-0560 IMD-0560 is a novel IκB kinase β inhibitor.
- GC34907 INH14 INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively.
- GN10370 Luteolin
- GC10093 LY2409881 LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
- GC61021 Malachite green oxalate Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo.
- GC15942 ML 120B dihydrochloride IKK2-selective inhibitor
- GC14989 MLN120B An IKKβ inhibitor
- GC66019 MLN120B dihydrochloride MLN120B dihydrochloride (ML120B dihydrochloride) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis.
- GC50093 MRT 68601 hydrochloride Potent TBK inhibitor
- GC17136 MRT67307 A kinase inhibitor
- GC13184 PF 184 PF 184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM.
- GC67890 PHA 408
- GN10503 Piceatannol
- GC12609 PS 1145 dihydrochloride IκB kinase (IKK) inhibitor
- GC17603 PS-1145 IKK inhibitor
- GC11751 QNZ (EVP4593) An inhibitor of NF-κB activation
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GC14553
Resveratrol
Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin
- GC12372 SC-514 ATP-competitive IKK-2 inhibitor, orally active
- GC10933 Sodium 4-Aminosalicylate Sodium 4-Aminosalicylate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.
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GC12013
Sodium salicylate
NF-κB inhibitor
- GN10737 Tanshinone IIA
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GC69998
TBK1-IN-1
TBK1-IN-1 is an effective selective inhibitor of TANK-binding kinase 1 (TBK1), with an IC50 value of 22.4 nM. TBK1-IN-1 inhibits the expression of downstream target genes cxcl10 and ifnβ of TBK1. TBK1-IN-1 has anti-cancer activity.
- GC37747 TBK1/IKKε-IN-1 TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.
- GC63212 TBK1/IKKε-IN-4 TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR.
- GC37748 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC50 values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity.
- GC16658 Vinpocetine PDE inhibitor
- GN10269 Wedelolactone
- GC13384 WS6 inducer of β cell proliferation