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IκB/IKK

IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.

Products for  IκB/IKK

  1. Cat.No. Product Name Information
  2. GC66334 (Rac)-PF-184 hydrate (Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects. (Rac)-PF-184 hydrate  Chemical Structure
  3. GC17416 ACHP IκB kinase inhibitor ACHP  Chemical Structure
  4. GC31319 Amlexanox (AA673) Amlexanox (AA673) (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM. Amlexanox (AA673)  Chemical Structure
  5. GN10718 Andrographolide Andrographolide  Chemical Structure
  6. GC10135 AZD3264 IKK2 inhibitor AZD3264  Chemical Structure
  7. GC10345 Bay 11-7085

    NK-κB activation inhibitor

    Bay 11-7085  Chemical Structure
  8. GC13035 Bay 11-7821

    A selective and irreversible NF-κB inhibitor

    Bay 11-7821  Chemical Structure
  9. GC35474 Bay 65-1942 free base Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor. Bay 65-1942 free base  Chemical Structure
  10. GC16303 Bay 65-1942 HCl salt Bay 65-1942 HCl salt  Chemical Structure
  11. GC35475 Bay 65-1942 R form Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 R form  Chemical Structure
  12. GC60624 BAY-985 A dual inhibitor of TBK1 and IKKε BAY-985  Chemical Structure
  13. GC18200 BI-605906 BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit β (IKKβ; IC50 = 380 nM). BI-605906  Chemical Structure
  14. GC32028 BMS-066 BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. BMS-066  Chemical Structure
  15. GC13926 BMS-345541(free base) BMS-345541(free base) is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541(free base) binds at an allosteric site of IKK. BMS-345541(free base)  Chemical Structure
  16. GC12399 BMS345541 hydrochloride A selective inhibitor of IKKα and IKKβ BMS345541 hydrochloride  Chemical Structure
  17. GC15083 Celastrol A triterpenoid antioxidant Celastrol  Chemical Structure
  18. GC35674 Chicanine Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity. Chicanine  Chemical Structure
  19. GC11170 Choline Fenofibrate Choline Fenofibrate  Chemical Structure
  20. GC17873 CID-2858522 A selective inhibitor of NF-κB activation CID-2858522  Chemical Structure
  21. GC16044 Emodin Natural CK2 inhibitor and ER agonist Emodin  Chemical Structure
  22. GC33816 Ertiprotafib (PTP 112) Ertiprotafib (PTP 112) is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. Ertiprotafib (PTP 112)  Chemical Structure
  23. GC43786 GS-143

    GS-143 is an inhibitor of IκBα ubiquitylation.

    GS-143  Chemical Structure
  24. GC65013 GSK8612 GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. GSK8612  Chemical Structure
  25. GC62161 HOIPIN-1 HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM. HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro. HOIPIN-1  Chemical Structure
  26. GN10664 Honokiol Honokiol  Chemical Structure
  27. GC63007 HPN-01 HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01  Chemical Structure
  28. GC12370 IKK-16 (hydrochloride) IκB kinases (IKKs) inhibitor IKK-16 (hydrochloride)  Chemical Structure
  29. GC12180 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK-16 (IKK Inhibitor VII)  Chemical Structure
  30. GC11508 IKK-2 inhibitor VIII IKK-2 inhibitor VIII  Chemical Structure
  31. GC10592 IKK-3 Inhibitor A multi-kinase inhibitor IKK-3 Inhibitor  Chemical Structure
  32. GC13278 IKKε-IN-1 potent IKKε inhibitor IKKε-IN-1  Chemical Structure
  33. GC17830 IMD 0354 IKKβ inhibitor IMD 0354  Chemical Structure
  34. GC33306 IMD-0560 IMD-0560 is a novel IκB kinase β inhibitor. IMD-0560  Chemical Structure
  35. GC34907 INH14 INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14  Chemical Structure
  36. GN10370 Luteolin Luteolin  Chemical Structure
  37. GC10093 LY2409881 LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM. LY2409881  Chemical Structure
  38. GC61021 Malachite green oxalate Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo. Malachite green oxalate  Chemical Structure
  39. GC15942 ML 120B dihydrochloride IKK2-selective inhibitor ML 120B dihydrochloride  Chemical Structure
  40. GC14989 MLN120B An IKKβ inhibitor MLN120B  Chemical Structure
  41. GC66019 MLN120B dihydrochloride MLN120B dihydrochloride (ML120B dihydrochloride) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis. MLN120B dihydrochloride  Chemical Structure
  42. GC50093 MRT 68601 hydrochloride Potent TBK inhibitor MRT 68601 hydrochloride  Chemical Structure
  43. GC17136 MRT67307 A kinase inhibitor MRT67307  Chemical Structure
  44. GC13184 PF 184 PF 184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. PF 184  Chemical Structure
  45. GC67890 PHA 408 PHA 408  Chemical Structure
  46. GN10503 Piceatannol Piceatannol  Chemical Structure
  47. GC12609 PS 1145 dihydrochloride IκB kinase (IKK) inhibitor PS 1145 dihydrochloride  Chemical Structure
  48. GC17603 PS-1145 IKK inhibitor PS-1145  Chemical Structure
  49. GC11751 QNZ (EVP4593) An inhibitor of NF-κB activation QNZ (EVP4593)  Chemical Structure
  50. GC14553 Resveratrol

    Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin

    Resveratrol  Chemical Structure
  51. GC12372 SC-514 ATP-competitive IKK-2 inhibitor, orally active SC-514  Chemical Structure
  52. GC10933 Sodium 4-Aminosalicylate Sodium 4-Aminosalicylate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis. Sodium 4-Aminosalicylate  Chemical Structure
  53. GC12013 Sodium salicylate

    NF-κB inhibitor

    Sodium salicylate  Chemical Structure
  54. GN10737 Tanshinone IIA Tanshinone IIA  Chemical Structure
  55. GC69998 TBK1-IN-1

    TBK1-IN-1 is an effective selective inhibitor of TANK-binding kinase 1 (TBK1), with an IC50 value of 22.4 nM. TBK1-IN-1 inhibits the expression of downstream target genes cxcl10 and ifnβ of TBK1. TBK1-IN-1 has anti-cancer activity.

    TBK1-IN-1  Chemical Structure
  56. GC37747 TBK1/IKKε-IN-1 TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM. TBK1/IKKε-IN-1  Chemical Structure
  57. GC63212 TBK1/IKKε-IN-4 TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR. TBK1/IKKε-IN-4  Chemical Structure
  58. GC37748 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC50 values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity. TBK1/IKKε-IN-5  Chemical Structure
  59. GC16658 Vinpocetine PDE inhibitor Vinpocetine  Chemical Structure
  60. GN10269 Wedelolactone Wedelolactone  Chemical Structure
  61. GC13384 WS6 inducer of β cell proliferation WS6  Chemical Structure

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