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Home >> Signaling Pathways >> Immunology/Inflammation >> IκB/IKK

IκB/IKK

IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.

Products for  IκB/IKK

  1. Cat.No. Product Name Information
  2. GC66334 (Rac)-PF-184 hydrate (Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects. (Rac)-PF-184 hydrate Chemical Structure
  3. GC74339 Ac2-26 ammonium Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium Chemical Structure
  4. GC17416 ACHP IκB kinase inhibitor ACHP Chemical Structure
  5. GC31319 Amlexanox (AA673)

    AA 673, CHX 3673, Elics

     Amlexanox (AA673) (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM. Amlexanox (AA673) Chemical Structure
  6. GN10718 Andrographolide Andrographolide Chemical Structure
  7. GC10135 AZD3264 IKK2 inhibitor AZD3264 Chemical Structure
  8. GC10345 Bay 11-7085

    NK-κB activation inhibitor

     Bay 11-7085 Chemical Structure
  9. GC13035 Bay 11-7821

    BAY 11-7082

     Bay 11-7821(BAY 11-7082) is an inhibitor of IκBα phosphorylation and NF-κB, selectively and irreversibly inhibits TNF-α-induced IκB-α phosphorylation (IC50 value is approximately 10μM), and reduces the expression of NF-κB and adhesion molecules. Bay 11-7821 inhibits ubiquitin-specific proteases USP7 and USP21 with IC50 values of 0.19 and 0.96μM, respectively . Bay 11-7821 Chemical Structure
  10. GC35474 Bay 65-1942 free base Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor. Bay 65-1942 free base Chemical Structure
  11. GC16303 Bay 65-1942 HCl salt Bay 65-1942 HCl salt Chemical Structure
  12. GC35475 Bay 65-1942 R form Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 R form Chemical Structure
  13. GC60624 BAY-985 A dual inhibitor of TBK1 and IKKε BAY-985 Chemical Structure
  14. GC18200 BI-605906 BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit β (IKKβ; IC50 = 380 nM). BI-605906 Chemical Structure
  15. GC19069 BI605906 BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP. BI605906 Chemical Structure
  16. GC32028 BMS-066 BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. BMS-066 Chemical Structure
  17. GC13926 BMS-345541(free base) BMS-345541(free base) is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541(free base) binds at an allosteric site of IKK. BMS-345541(free base) Chemical Structure
  18. GC12399 BMS345541 hydrochloride

    IKK Inhibitor III

     A selective inhibitor of IKKα and IKKβ BMS345541 hydrochloride Chemical Structure
  19. GC15083 Celastrol Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC50 of 2.5 μM. Celastrol Chemical Structure
  20. GC35674 Chicanine Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity. Chicanine Chemical Structure
  21. GC11170 Choline Fenofibrate Choline Fenofibrate Chemical Structure
  22. GC17873 CID-2858522

    CID 2858522;CID2858522

     A selective inhibitor of NF-κB activation CID-2858522 Chemical Structure
  23. GC16044 Emodin

    Archin, Frangulic Acid, NSC 408120, NSC 622947, Schuttgelb

     Natural CK2 inhibitor and ER agonist Emodin Chemical Structure
  24. GC33816 Ertiprotafib (PTP 112)

    PTP 112

     Ertiprotafib (PTP 112) is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. Ertiprotafib (PTP 112) Chemical Structure
  25. GC20007 Ginsenoside CK

    Ginsenoside Compound K, Ginsenoside IH901; Compound K

    Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

     Ginsenoside CK Chemical Structure
  26. GC43786 GS-143

    GS-143 is an inhibitor of IκBα ubiquitylation.

     GS-143 Chemical Structure
  27. GC65013 GSK8612 GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. GSK8612 Chemical Structure
  28. GC62161 HOIPIN-1

    JTP-0819958

     HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM. HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro. HOIPIN-1 Chemical Structure
  29. GN10664 Honokiol

    NSC 293100

     Honokiol is a natural bisphenol chemical with multiple biological activities. It targets multiple signaling molecules and has effective antioxidant, anti-inflammatory, anti-angiogenic and anti-cancer activities. It also has broad-spectrum antibacterial and anti-human immunodeficiency virus (HIV) activities. Honokiol Chemical Structure
  30. GC63007 HPN-01 HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 Chemical Structure
  31. GC12370 IKK-16 (hydrochloride)

    IKK Inhibitor VII

     IκB kinases (IKKs) inhibitor IKK-16 (hydrochloride) Chemical Structure
  32. GC12180 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK-16 (IKK Inhibitor VII) Chemical Structure
  33. GC11508 IKK-2 inhibitor VIII IKK-2 inhibitor VIII Chemical Structure
  34. GC10592 IKK-3 Inhibitor

    GSK 319347A

     A multi-kinase inhibitor IKK-3 Inhibitor Chemical Structure
  35. GC13278 IKKε-IN-1 potent IKKε inhibitor IKKε-IN-1 Chemical Structure
  36. GC17830 IMD 0354

    IKK2 Inhibitor V

     IKKβ inhibitor IMD 0354 Chemical Structure
  37. GC33306 IMD-0560 IMD-0560 is a novel IκB kinase β inhibitor. IMD-0560 Chemical Structure
  38. GC34907 INH14 INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 Chemical Structure
  39. GN10370 Luteolin Luteolin is a flavonoid compound with multiple functions such as anti-inflammatory, antioxidant, and anti-cancer. Luteolin is an effective inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2). Luteolin Chemical Structure
  40. GC10093 LY2409881 LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM. LY2409881 Chemical Structure
  41. GC61021 Malachite green oxalate Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo. Malachite green oxalate Chemical Structure
  42. GC15942 ML 120B dihydrochloride IKK2-selective inhibitor ML 120B dihydrochloride Chemical Structure
  43. GC14989 MLN120B An IKKβ inhibitor MLN120B Chemical Structure
  44. GC66019 MLN120B dihydrochloride

    ML120B dihydrochloride

     MLN120B dihydrochloride (ML120B dihydrochloride) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis. MLN120B dihydrochloride Chemical Structure
  45. GC50093 MRT 68601 hydrochloride Potent TBK inhibitor MRT 68601 hydrochloride Chemical Structure
  46. GC17136 MRT67307 A kinase inhibitor MRT67307 Chemical Structure
  47. GC13184 PF 184 PF 184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. PF 184 Chemical Structure
  48. GC67890 PHA 408 PHA 408 Chemical Structure
  49. GN10503 Piceatannol

    Astringenin, transPicetannol, trans3,3',4,5'Tetrahydroxystilbene

     Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol. Piceatannol Chemical Structure
  50. GC12609 PS 1145 dihydrochloride IκB kinase (IKK) inhibitor PS 1145 dihydrochloride Chemical Structure
  51. GC17603 PS-1145

    IKK Inhibitor X

     IKK inhibitor PS-1145 Chemical Structure
  52. GC11751 QNZ (EVP4593)

    CAY10470

     An inhibitor of NF-κB activation QNZ (EVP4593) Chemical Structure
  53. GC14553 Resveratrol

    (E)Resveratrol

     Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin. Resveratrol Chemical Structure
  54. GC12372 SC-514

    GK 01140

     ATP-competitive IKK-2 inhibitor, orally active SC-514 Chemical Structure
  55. GC10933 Sodium 4-Aminosalicylate Sodium 4-Aminosalicylate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis. Sodium 4-Aminosalicylate Chemical Structure
  56. GC12013 Sodium salicylate

    NF-κB inhibitor

     Sodium salicylate Chemical Structure
  57. GN10737 Tanshinone IIA

    NSC 686518, NSC 686519, TSA

     Tanshinone IIA is a major tanshinone isolated from Salvia divinorum. Commonly used in cardiovascular disease and cancer research. Tanshinone IIA Chemical Structure
  58. GC69998 TBK1-IN-1

    TBK1-IN-1 is an effective selective inhibitor of TANK-binding kinase 1 (TBK1), with an IC50 value of 22.4 nM. TBK1-IN-1 inhibits the expression of downstream target genes cxcl10 and ifnβ of TBK1. TBK1-IN-1 has anti-cancer activity.

     TBK1-IN-1 Chemical Structure
  59. GC37747 TBK1/IKKε-IN-1 TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM. TBK1/IKKε-IN-1 Chemical Structure
  60. GC63212 TBK1/IKKε-IN-4 TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR. TBK1/IKKε-IN-4 Chemical Structure
  61. GC37748 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC50 values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity. TBK1/IKKε-IN-5 Chemical Structure
  62. GC16658 Vinpocetine

    Apovincaminic Acid ethyl ester, AY 27255, RGH-4405

     PDE inhibitor Vinpocetine Chemical Structure
  63. GN10269 Wedelolactone

    IKK Inhibitor II

     Wedelolactone Chemical Structure
  64. GC13384 WS6 inducer of β cell proliferation WS6 Chemical Structure

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