GLPBio

MEK1/2

MEK1/2, also known as MAPKK (mitogen-activated protein kinase kinase), is a kinase enzyme which phosphorylates MAPK (mitogen-activated protein kinase).

Products Related to MEK1/2(75)

  • GC15646 structure
    GC15646PD 184161
    CAS: 212631-67-9
    Purity: >98%

    MEK1/2 inhibitor

  • GC15693 structure
    GC15693BIX 02188
    CAS: 334949-59-6
    Purity: >99.50%

    MEK5 inhibitor,potent and selective

  • GC16001 structure
    GC16001SCH772984
    CAS: 942183-80-4
    Purity: >98.50%

    SCH772984 is a novel, potent, ATP-competitive inhibitor of ERK1 and ERK2 with IC 50 values of 4nM and 1nM, respectively.

  • GC17030 structure
    GC17030AZD6244(Selumetinib)
    CAS: 606143-52-6
    Purity: >99.00%

    AZD6244(Selumetinib) is an oral, small molecule, specific ATP non-competitive inhibitor of MEK1/2 proteins, with the IC 50 of 14.1 ± 0.79nM.

  • GC17426 structure
    GC17426Cobimetinib (racemate)
    CAS: 934662-91-6
    Purity: >99.50%
  • GC17485 structure
    GC17485PD 334581
    CAS: 548756-68-9
    Purity: >98%

    MEK1 inhibitor

  • GC17608 structure
    GC17608Lidocaine
    CAS: 137-58-6
    Purity: >99.50%

    Anasthetic and class Ib antiarrhythmic agent

  • GC17828 structure
    GC17828BI-847325
    CAS: 1207293-36-4
    Purity: >99.00%

    dual inhibitor of MEK and Aurora kinases

  • GC17964 structure
    GC17964PD 198306
    CAS: 212631-61-3
    Purity: >98%

    MEK1/2 inhibitor

  • GC30162 structure
    GC30162trans-Zeatin
    CAS: 1637-39-4
    Purity: >98.50%

    trans-Zeatin is a natural cytokinin, a plant growth regulator that plays a central role in plant cell growth, differentiation, and division.

  • GC33305 structure
    GC33305Balamapimod (MKI 833)
    CAS: 863029-99-6
    Purity: >98%

    Balamapimod (MKI 833) (MKI 833) is a reversible Ras/Raf/MEK inhibitor with potential anti-tumor activity.

  • GC33388 structure
    GC33388MEK-IN-1
    CAS: 870600-45-6
    Purity: >98%

    MEK-IN-1 is a MEK inhibitor extracted from patent WO2008076415A1.

  • GC33468 structure
    GC33468Rehmannioside A
    CAS: 81720-05-0
    Purity: >98.00%

    Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively.

  • GC33831 structure
    GC33831Lidocaine hydrochloride (Lignocaine hydrochloride)
    CAS: 73-78-9
    Purity: >98.00%

    Lidocaine hydrochloride (Lignocaine hydrochloride) is an amino-amide-type local anaesthetic that inhibits voltage-insensitive ‘flicker’ K + channel with an IC 50 value of 220μM.

  • GC35684 structure
    GC35684CHMFL-EGFR-202
    CAS: 2089381-40-6
    Purity: >98%

    CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ?10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines.

  • GC35719 structure
    GC35719Cobimetinib hemifumarate
    CAS: 1369665-02-0
    Purity: >99.00%

    Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM.

  • GC36199 structure
    GC36199GW284543
    CAS: 790186-68-4
    Purity: >99.50%

    GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.

  • GC37516 structure
    GC37516Refametinib R enantiomer
    CAS: 923032-38-6
    Purity: >98%

    Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM.

  • GC37522 structure
    GC37522RGB-286638
    CAS: 784210-87-3
    Purity: >99.50%

    A multi-kinase inhibitor

  • GC37523 structure
    GC37523RGB-286638 free base
    CAS: 784210-88-4
    Purity: >98%

    A multi-kinase inhibitor

  • GC38653 structure
    GC38653Selumetinib sulfate
    CAS: 943332-08-9
    Purity: >99.00%

    Selumetinib (AZD6244) is selective, non-ATP-competitive oral?MEK1/2?inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation.

  • GC41573 structure
    GC41573Theaflavin 3,3'-digallate
    CAS: 30462-35-2
    Purity: >98.00%

    Theaflavin 3,3'-digallate (TF-3; ZP10) is a potent inhibitor of Zika virus (ZIKV) protease with an IC 50 value of 2.3μM.

  • GC43885 structure
    GC43885Hypothemycin
    CAS: 76958-67-3
    Purity: >95.00%

    A resorcylic acid lactone polyketide

  • GC45099 structure
    GC45099U-0126
    CAS: 109511-58-2
    Purity: >98.00%

    A MEK inhibitor