Estrogen Receptor/ERR

3'-Hydroxymirificin (compound 3) is a natural product that can be obtained from the roots of Pueraria lobata. It has estrogenic and anti-proliferative activity against MCF-7 human breast cancer cells.

4-Nonylphenol-d5 is the deuterated form of 4-nonylphenol. 4-nonylphenol is the main degradation product of nonylphenol ethoxylates (NPEOs), a persistent organic pollutant with endocrine disrupting properties and estrogenic activity.

Cholesterol-d4 is the deuterated form of cholesterol. Cholesterol is a major sterol in mammals, comprising 20-25% of membrane structural components. The membrane has high permeability to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of transport proteins and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor alpha (ERRα) agonist.

Estradiol benzoate-d3 is the deuterated form of estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate) is a precursor active molecule of estradiol, which is a type of steroid hormone. Estradiol Benzoate exhibits slight synthetic metabolic properties and increases blood clotting.

FSHR agonist 1 is a high-affinity and allosteric follicle-stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 interacts extensively with the transmembrane domain to directly activate FSHR.

GNE-149 is an effective and orally active estrogen receptor alpha (ERα; IC50=0.053 nM) antagonist. It is also a selective estrogen receptor degrader (SERD). GNE-149 can be used for research on breast cancer.

Imlunestrant (LY-3484356) is an orally effective and selective estrogen receptor (ER) degrader (SERD) with pure antagonistic properties. Imlunestrant can sustainably inhibit ER-dependent gene transcription and cell growth. Imlunestrant can be used in the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid carcinoma (EEC).

Imlunestrant (LY-3484356) tosylate is an orally effective and selective estrogen receptor (ER) degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate can sustainably inhibit ER-dependent gene transcription and cell growth. It can be used for research on ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid carcinoma (EEC).

Yp537 TFA is an estrogen receptor (ER) inhibitor that can prevent dimerization of human estrogen receptors.

Zuclomiphene-d4 (citrate) is the deuterated form of Zuclomiphene citrate. Zuclomiphene citrate has anti-estrogenic effects and is more effective than its trans-isomer in inhibiting the secretion of luteinizing hormone (LH). It is also an orally active cholesterol-lowering agent.

Inokosterone is a potential agent target of estrogen receptor 1 in rheumatoid arthritis patients.

ERRγ agonist-1 is a potent ERRγ agonist.

Palazestrant is an antiestrogen and antineoplastic agent.

SLU-PP-1072 is a dual ERRα/γ inverse agonist, used in Prostate cancer (PCa) research.

SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively.

Bisphenol AF-d4 is the isotope labelled analog of Bisphenol AF .

LY117018 TFA, a Raloxifene analog, is a selective estrogen receptor modulator.

AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha.

Nafoxidine, a nonsteroidal estrogen antagonist, is shown to possess antitumor activity against breast cancer.

CIDD-0149897 is a potent, selective and brain-penetrant ERβ agonist.

PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization and degradation of estrogen receptor ERβ (DC50:~2 nM, HEK293T).

Fumagilin-105 is an autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization with DC50 values of 0.7 μM for MetAP2 in HEK293 cells.

PROTAC AR Degrader-12 is a highly efficient PROTAC targeting AR coactivator binding site (AR-CBS).

ZN-c5 hydrochloride is a selective and orally active estrogen receptor degrader.