Guanylate Cyclase
GC (guanylyl cyclaese) converts GTP into cGMP and pyrophosphate. sGC (soluble GC) is a nitric oxide receptor and pGC (transmembrance GC) is a natriiuritic peptide receptor. Its major functions include cell hyperplasia,hypertrophy, cell differentiation and tumor progression etc.
Products Related to Guanylate Cyclase (29)
- GC65449PraliciguatCAS: 1628730-49-3Purity: >98.00%
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator.
- GC68741BAY-747CAS: 1609342-18-8Purity: >98%
BAY-747 (BAY 1165747) is an orally effective and brain-penetrant soluble guanylate cyclase (sGC) stimulator. BAY-747 reverses L-NAME-induced memory impairment and enhances cognition in rats. It also lowers conscious blood pressure in both normotensive and spontaneously hypertensive rats (SHR). Additionally, BAY-747 improves skeletal muscle function associated with Duchenne muscular dystrophy (DMD) in the mdx/mTRG2 mouse model.
- GC69277IndusatumabCAS: 1497400-26-6Purity: >95.00%
Indusatumab (5F9 monoclonal antibody) is a monoclonal antibody that targets anti-human GUCY2C (Guanylate cyclase 2C).
- GC74357DolcanatideCAS: 1092457-65-2Purity: >99.00%
Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist.
- GC74390Guanylin (mouse, rat) (TFA)Purity: >95.00%
Guanylin (mouse, rat) TFA, a petide, is composed of 15 amino acids.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC65449 | Praliciguat | 1628730-49-3 | >98.00% | |
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. | ||||
| GC68741 | BAY-747 | 1609342-18-8 | >98% | |
BAY-747 (BAY 1165747) is an orally effective and brain-penetrant soluble guanylate cyclase (sGC) stimulator. BAY-747 reverses L-NAME-induced memory impairment and enhances cognition in rats. It also lowers conscious blood pressure in both normotensive and spontaneously hypertensive rats (SHR). Additionally, BAY-747 improves skeletal muscle function associated with Duchenne muscular dystrophy (DMD) in the mdx/mTRG2 mouse model. | ||||
| GC69277 | Indusatumab | 1497400-26-6 | >95.00% | |
Indusatumab (5F9 monoclonal antibody) is a monoclonal antibody that targets anti-human GUCY2C (Guanylate cyclase 2C). | ||||
| GC74357 | Dolcanatide | 1092457-65-2 | >99.00% | |
Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. | ||||
| GC74390 | Guanylin (mouse, rat) (TFA) | - | >95.00% | |
Guanylin (mouse, rat) TFA, a petide, is composed of 15 amino acids. | ||||