Aldehyde Dehydrogenase (ALDH)

Aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast cancer stem cells (CSCs), in triple negative breast cancer (TNBC) tissues.

Mitochondrial aldehyde dehydrogenase (ALDH2) is a member of the 19-strong human aldehyde dehydrogenase family of NADP⁺-dependent enzymes.

ALDH2, a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. Activation of ALDH2, the main enzyme that catalyzes 4-HNE metabolism, is sufficient to protect the heart against acute ischemia-reperfusion injury.

ALDH2 is a key detoxifying enzyme. ALDH2 is most commonly associated with its role in ethanol metabolism, catalyzing the oxidation of ethanol-derived acetaldehyde to acetate.

Products Related to Aldehyde Dehydrogenase (ALDH)(31)

GC68635 ALDH3A1-IN-1
CAS: 1039855-56-5
Purity: >98%
ALDH3A1-IN-1 (Compound 18) is an effective inhibitor of ALDH3A1 with an IC50 of 1.61 μM. As a monotherapy or in combination with docetaxel, ALDH3A1-IN-1 is more effective than DEAB on primary prostate tumor epithelial cells derived from patients.
GC69260 IGUANA-1
CAS: 2756014-25-0
Purity: >98%
IGUANA-1 is an efficient inhibitor of ALDH1B1, which is a mitochondrial enzyme that promotes colorectal and pancreatic cancer. IGUANA-1 has significant inhibitory effects on cancer cells.
GC69342 KS100
CAS: 2408477-54-1
Purity: >98%
KS100 is an effective ALDH inhibitor with IC50 values of 334, 2137, and 360 nM for ALDH1A1, ALDH2, and ALDH3A1 respectively. It has low toxicity and exhibits anti-proliferative and anti-cancer effects. KS100 significantly increases ROS activity, lipid peroxidation, and accumulation of toxic aldehydes. KS100 induces apoptosis and cell cycle arrest at the G2/M phase.
GC71432 FSI-TN42
CAS: 2445840-25-3
Purity: >98.00%
GC72957 ALDH3A1-IN-3
CAS: 315239-63-5
Purity: >99.00%
ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a Ki value of 4.7 μM and an IC50 value of 16 μM.
GC73645 YG1702
CAS: 724737-08-0
Purity: >99.00%
YG1702 is a potent ALDH18A1-specific inhibitor.
GC79558 ALDH3A1-IN-4
CAS: 324777-01-7
Purity: >99.50%
ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC 50 of 0.2 μM.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC68635	ALDH3A1-IN-1	1039855-56-5	>98%
GC68635	ALDH3A1-IN-1 (Compound 18) is an effective inhibitor of ALDH3A1 with an IC50 of 1.61 μM. As a monotherapy or in combination with docetaxel, ALDH3A1-IN-1 is more effective than DEAB on primary prostate tumor epithelial cells derived from patients.
GC69260	IGUANA-1	2756014-25-0	>98%
GC69260	IGUANA-1 is an efficient inhibitor of ALDH1B1, which is a mitochondrial enzyme that promotes colorectal and pancreatic cancer. IGUANA-1 has significant inhibitory effects on cancer cells.
GC69342	KS100	2408477-54-1	>98%
GC69342	KS100 is an effective ALDH inhibitor with IC50 values of 334, 2137, and 360 nM for ALDH1A1, ALDH2, and ALDH3A1 respectively. It has low toxicity and exhibits anti-proliferative and anti-cancer effects. KS100 significantly increases ROS activity, lipid peroxidation, and accumulation of toxic aldehydes. KS100 induces apoptosis and cell cycle arrest at the G2/M phase.
GC71432	FSI-TN42	2445840-25-3	>98.00%
GC72957	ALDH3A1-IN-3	315239-63-5	>99.00%
GC72957	ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a Ki value of 4.7 μM and an IC50 value of 16 μM.
GC73645	YG1702	724737-08-0	>99.00%
GC73645	YG1702 is a potent ALDH18A1-specific inhibitor.
GC79558	ALDH3A1-IN-4	324777-01-7	>99.50%
GC79558	ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC 50 of 0.2 μM.