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Home >> Signaling Pathways >> Proteases >> Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

Aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast cancer stem cells (CSCs), in triple negative breast cancer (TNBC) tissues.

Mitochondrial aldehyde dehydrogenase (ALDH2) is a member of the 19-strong human aldehyde dehydrogenase family of NADP+-dependent enzymes.

ALDH2, a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. Activation of ALDH2, the main enzyme that catalyzes 4-HNE metabolism, is sufficient to protect the heart against acute ischemia-reperfusion injury.

ALDH2 is a key detoxifying enzyme. ALDH2 is most commonly associated with its role in ethanol metabolism, catalyzing the oxidation of ethanol-derived acetaldehyde to acetate.

Targets for  Aldehyde Dehydrogenase (ALDH)

Products for  Aldehyde Dehydrogenase (ALDH)

  1. Cat.No. Product Name Information
  2. GC39328 3-Hydroxybenzaldehyde 3-Hydroxybenzaldehyde?is a precursor compound for phenolic compounds, such as Protocatechualdehyde. 3-Hydroxybenzaldehyde Chemical Structure
  3. GC39245 4-Diethylaminobenzaldehyde 4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM). 4-Diethylaminobenzaldehyde Chemical Structure
  4. GC42410 4-hydroxy Nonenal

    A lipid peroxidation product

     4-hydroxy Nonenal Chemical Structure
  5. GC50613 673 A ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) 673 A Chemical Structure
  6. GC16597 Alda 1

    ALDH2 activator

     Alda 1 Chemical Structure
  7. GC64063 ALDH1A1-IN-2 ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295). ALDH1A1-IN-2 Chemical Structure
  8. GC67782 ALDH1A2-IN-1 ALDH1A2-IN-1 Chemical Structure
  9. GC68464 ALDH1A3-IN-1 ALDH1A3-IN-1 Chemical Structure
  10. GC68462 ALDH1A3-IN-2 ALDH1A3-IN-2 Chemical Structure
  11. GC64618 ALDH1A3-IN-3 ALDH1A3-IN-3 (compound 16) is a potent inhibitor of ALDH1A3, with an IC50 of 0.26 μM. ALDH1A3-IN-3 is also a good ALDH3A1 substrate. ALDH1A3-IN-3 can be used for the research of prostate cancer. ALDH1A3-IN-3 Chemical Structure
  12. GC60092 BODIPY aminoacetaldehyde BODIPY aminoacetaldehyde (BAAA) is a fluorescent substrate for both murine and human aldehyde dehydrogenase (ALDH). BODIPY aminoacetaldehyde consists of an aminoacetaldehyde moiety bonded to the BODIPY fluorochrome and can be used to label stem cells. BODIPY aminoacetaldehyde Chemical Structure
  13. GC43285 CM037 CM037 is a selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; IC50 = 4.6 μM). CM037 Chemical Structure
  14. GC39215 CM10 CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 Chemical Structure
  15. GC10902 CVT 10216 reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) CVT 10216 Chemical Structure
  16. GC10801 Disulfiram An irreversible inhibitor of aldehyde dehydrogenase Disulfiram Chemical Structure
  17. GC38909 EN40

    EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM

     EN40 Chemical Structure
  18. GC68009 KS106 KS106 Chemical Structure
  19. GC10016 NCT-501

    Aldehyde Dehydrogenase 1A1 (ALDH1A1) inhibitor, Potent and Selective

     NCT-501 Chemical Structure
  20. GC44338 NCT-501 (hydrochloride) Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)+-dependent oxidation of aldehyde-containing substrates to the corresponding carboxylic acids. NCT-501 (hydrochloride) Chemical Structure
  21. GC33219 NCT-505 NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM). NCT-505 Chemical Structure
  22. GC65274 NCT-506 NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM. NCT-506 Chemical Structure
  23. GC46002 Prunetin An isoflavone with diverse biological activities Prunetin Chemical Structure
  24. GC37576 RV01 RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity. RV01 Chemical Structure
  25. GC63605 Taraxerone Taraxerone is isolated from Sedum sarmentosum. Taraxerone Chemical Structure

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