Drug Metabolite

Omeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole.

p,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.

Pantoprazole sulfide is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole.

Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole.

Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension.

Phenylephrine glucuronide is a metabolite of the α1A-adrenergic receptor agonist phenylephrine .

Phenylephrine-3-O-sulfate is metabolite of the α1A-adrenergic receptor agonist phenylephrine formed via sulfation.

Pitavastatin lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase, that is found in plasma of rats and humans following oral administration.

PNU 142300 is an inactive metabolite of the oxazolidinone antibiotic linezolid .

Posaconazole D-glucuronide is a metabolite of the antifungal agent posaconazole.

Pravastatin lactone is a metabolite of pravastatin, a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin.

Propranolol β-D-glucuronide is a major metabolite of propranolol.

Quinidine N-oxide is a pharmacologically inactive quinidine metabolite.

rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol).

Reduced haloperidol is an active metabolite of haloperidol.

Resveratrol-3-O-sulfate (sodium) is the metabolite of Resveratrol.

Silodosin glucuronide is an active metabolite of the α1A-adrenergic receptor antagonist silodosin.

Sitagliptin N-sulfate is a phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin.

Solifenacin N-glucuronide is a metabolite of the muscarinic receptor antagonist solifenacin formed by direct glucuronidation.

Solifenacin N-oxide is an inactive metabolite of the muscarinic receptor antagonist solifenacin.

Sorafenib N-oxide is an active metabolite of sorafenib, an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases.

Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM.

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan.

Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM).