Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Targets for Drug Metabolite
Products for Drug Metabolite
- Cat.No. Product Name Information
-
GC45208
α-hydroxy Metoprolol
α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
-
GC40480
α-Phenyl-α-(2-pyridyl)acetonitrile
NSC 16276, 2-Pyridylphenylacetonitrile
α-Phenyl-α-(2-pyridyl)thioacetamide, also known as antigastrin and SC-15396, is an inhibitor of gastric acid secretion.
-
GC41661
(±)-4-hydroxy Propranolol β-D-Glucuronide
(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
-
GC46284
(±)-Cotinine-d3
An internal standard for the quantification of cotinine
-
GC41671
(±)-Equol 4'-sulfate (sodium salt)
R,S-Equol 4'-Sulfate
(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol.
-
GC41315
(±)-Ketoprofen Glucuronide
rac-Ketoprofen Acyl-β-D-glucuronide, (R,S)-Ketoprofen Glucuronide
(±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen.
-
GC49875
(±)-N-desmethyl Venlafaxine (hydrochloride)
Wy 45494
A minor active metabolite of venlafaxine
-
GC45252
(-)-Sitagliptin Carbamoyl Glucuronide
(R)-Sitagliptin Carbamoyl Glucuronide
(-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin.
-
GC18622
(2'S)-Nicotine-1-oxide
Nicotine-N-oxide
(2'S)-Nicotine-1-oxide is a metabolite of nicotine .
-
GC68509
(25R)-12α-Hydroxyspirost-4-en-3-one
(25R)-12α-Hydroxyspirost-4-en-3-one is a secondary metabolite produced by Nocardia globerula from Hecogenin.
-
GC41694
(3S)-hydroxy Quinidine
(3S)-hydroxy Quinidine is an active quinidine metabolite.
-
GC60399
(E)-10-Hydroxynortriptyline
10(E)-hydroxy Nortriptyline
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline.
-
GC91418
(E)-KPT-330
KTP-330; trans Selinexor
(E)-KPT-330 is a metabolite of the exportin 1 (XPO1/CRM1) inhibitor selinexor.
-
GC40286
(E,Z)-2-propyl-2-Pentenoic Acid
2-propyl-2-Pentenoate, 2-propylpenten-2-oic Acid, 2-ene-VPA
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.
-
GC49189
(E/Z)-4-hydroxy Tamoxifen-d5
Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
-
GC62737
(R)-(-)-O-Desmethyl Venlafaxine D6
-
GC41722
(R,S)-Carvedilol Glucuronide
(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
-
GC60410
(Rac)-3′-Hydroxy simvastatin
(Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin.
-
GC41736
(S)-Dibutyl 3-Hydroxybutyl Phosphate
(S)TBPOH
Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP).
-
GC40145
(S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
-
GC49179
(S)-O-Desmethyl Naproxen
(S)-6-Desmethyl Naproxen
A metabolite of (S)-naproxen
-
GC60419
(S)-O-Desmethyl Venlafaxine N-Oxide
(S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine.
-
GC60427
(Z)-10-Hydroxynortriptyline
10(Z)-hydroxy Nortriptyline
(Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline.
-
GC67761
(Z)-10-Hydroxynortriptyline-d3
-
GC18596
(±)-2-propyl-4-Pentenoic Acid
2-Allylpentanoic Acid, 4-ene VPA
(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid .
-
GC41837
1,3,7-Trimethyluric Acid
8-oxo Caffeine, NSC 11259
1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.
-
GC46387
1,3,7-Trimethyluric Acid-d9
TMU-d9, 8-oxo Caffeine-d9
An internal standard for the quantification of 1,3,7-trimethyluric acid
-
GC49294
1-(4-Chlorobenzhydryl)piperazine
N-(p-Chlorobenzhydryl)-piperazine, Norchlorcyclizine, NSC 86164
An inactive metabolite of meclizine and chlorcyclizine
-
GC49366
1-Salicylate Glucuronide
Salicyl Phenolic Glucuronide, Salicylic Acid Phenolic Glucuronide
A metabolite of salicylic acid and aspirin
-
GC49820
10,11-dihydro-10,11-dihydroxy Carbamazepine
10,11-dihydro-10,11-dihydroxy CBZ, CBZ-diol, Dihydroxycarbazepine, Dihydroxycarbamazepine
A metabolite of carbamazepine and oxcarbazepine
-
GC66057
10,11-Dihydrocarbamazepine
10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy.
-
GC49118
10-hydroxy Warfarin
A metabolite of (R)-warfarin
-
GC49759
13C17-Mycophenolic Acid
13C17-MPA
An internal standard for the quantification of mycophenolic acid
-
GC19442
15-Acetyldeoxy Nivalenol
15-Acetyl Vomitoxin, 15-AcDON, Deoxynivalenol 15-acetate, DON 15-acetate
15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops.
-
GC41937
15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
15ketoBimatoprost, 17phenyl trinor PGF2α ethyl amide
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.
-
GC41309
16α-hydroxy Prednisolone
16α-hydroxy Prednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide.
-
GC41300
17β-hydroxy Exemestane
17β-hydroxy Exemestane is the primary active metabolite of exemestane.
-
GC46471
17β-hydroxy Exemestane-d3
A neuropeptide with diverse biological activities
-
GC71042
18β-Glycyrrhetyl-3-O-sulfate
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome.
-
GC49823
2′-C-β-Methylguanosine
An active nucleoside metabolite of BMS-986094
-
GC46508
2',2'-Difluoro-2'-deoxyuridine
dFdU
An active metabolite of gemcitabine
-
GC49159
2-(1-Piperazinyl)pyrimidine
PmP, 1-PP, 1-(2-Pyrimidyl)piperazine
An α2-AR antagonist and active metabolite of azapirones
-
GC49330
2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride)
A metabolite of mazindol
-
GC52029
2-Aminoflubendazole
Hydrolyzed Flubendazole
-
GC46539
2-Chloroadenine
6-amino-2-chloropurine, 2-chloro-6-aminopurine, NSC 7362
A heterocyclic building block
-
GC40675
2-deoxy-Artemisinin
2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
-
GC35090
2-Hydroxy atorvastatin calcium salt
o-hydroxy Atorvastatin, ortho-hydroxy Atorvastatin, BMS 243887-01, PD 152873
An active metabolite of atorvastatin
-
GC60474
2-Hydroxy atorvastatin lactone
2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin.
-
GC64336
2-Hydroxyemodin
2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes.
-
GC41154
2-keto-D-Glucose
D-Glucosone
2-keto-D-Glucose is a key intermediate in the biosynthetic pathway of the antibiotic cortalcerone and a metabolic intermediate in the conversion of D-glucose to D-fructose.
-
GC62777
2-Methoxy-4-vinylphenol
2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects.
-
GC70763
2-NP-AMOZ
2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
-
GC42189
2-oxo Clopidogrel
2-oxo Clopidogrel is an intermediary metabolite of clopidogrel.
-
GC40968
21-hydroxy Eplerenone
21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone.
-
GC35079
24, 25-Dihydroxy VD2
24, 25-Dihydroxy VD2 is a hydroxylated metabolite of vitamin D2, and a synthetic vitamin D analog.
-
GC49365
25-Desacetyl Rifampicin
Desacetylrifampicin
A major active metabolite of rifampicin
-
GC62033
3α-Hydroxy pravastatin sodium
3α-Isopravastatin, R-416
3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin.
-
GC41480
3'-hydroxy Lidocaine
m-hydroxy Lidocaine, meta-hydroxy Lidocaine
3'-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.
-
GC39611
3'-Hydroxy Repaglinide
3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide.
-
GC60500
3'-Hydroxy Repaglinide D5
3'-Hydroxy Repaglinide D5 is the deuterium labeled 3'-Hydroxy Repaglinide.
-
GC68082
3,4,5-Trimethoxyphenylacetic acid
-
GC39841
3,4-Dehydro Cilostazol
OPC 13015
3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol.
-
GC52324
3-(3-Hydroxyphenyl)propionic Acid sulfate
3-HPPA sulfate
A metabolite of certain phenols and glycosides
-
GC42198
3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt)
γ-Hydroxybaclofen
An inactive metabolite of baclofen
-
GC46583
3-Amino-2,6-Piperidinedione
α-Aminoglutarimide, 3-Aminoglutarimide, Glutamimide
An active metabolite of (±)-thalidomide
-
GC67902
3-Amino-2-oxazolidinone-d4
AOZ-d4
-
GC42274
3-hydroxy Darifenacin
UK 148993
3-hydroxy Darifenacin is a metabolite of darifenacin.
-
GC42275
3-hydroxy Desloratidine
SCH 45581
3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.
-
GC41565
3-hydroxy Medetomidine
3-OH Medetomidine, Medetomidine metabolite MIII
3-hydroxy Medetomidine is a metabolite of the α2-adrenergic receptor agonist medetomidine.
-
GC48457
3-keto Fusidic Acid
3-keto FA, 3-Oxofusidic Acid
An active metabolite of fusidic acid
-
GC33738
3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride)
3-Methoxy-4-hydroxyphenethylamine, 3-Methoxy-p-hydroxyphenethylamine, 3-O-methyl Dopamine
3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
-
GC68324
3-Methoxytyramine-d4 hydrochloride
3-O-methyl Dopamine-d4 hydrochloride
-
GC49869
3-Methoxytyrosine
DL-3-O-Methyldopa, NSC 122476, 3-methoxy-DL-Tyrosine
An active metabolite of L-DOPA
-
GC42307
3-O-methyl-L-DOPA (hydrate)
3-O-methyl-3,4-Dihydroxyphenylalanine, 3-methoxy DOPA, 3-OMD
3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase.
-
GC49367
4’-hydroxy Atomoxetine Glucuronide (hydrate)
A metabolite of atomoxetine
-
GC49252
4’-hydroxy Trazodone
A metabolite of trazodone
-
GC18527
4'-hydroxy Flurbiprofen
A major active metabolite of flurbiprofen
-
GC49752
4,5-Desisopropylidene Topiramate
4,5-Desisopropylidene TPM
An inactive metabolite of topiramate
-
GC49337
4-Acetamidobenzenesulfonamide
APAS, N-Acetyl p-Aminobenzene Sulfonamide, N4-Acetyl Sulfanilamide, N-Acetylsulfanilamide, NSC 217, NSC 406839
A metabolite of asulam and sulfanilamide
-
GC42370
4-desmethoxy Omeprazole
4-desmethoxy OMEP, 4-desmethoxy OMP, 4-desmethoxy OMZ, Esomeprazol Magnesium Impurity B, Omeprazole EP Impurity B
4-desmethoxy Omeprazole is a potential impurity found in commercial omeprazole and esomeprazole magnesium preparations.
-
GC18194
4-Epidoxycycline
4-ED
4-Epidoxycycline is the 4-epimer hepatic metabolite of the antibiotic doxycycline .
-
GC42401
4-hydroperoxy Cyclophosphamide
4-OOH-CY
4-hydroperoxy Cyclophosphamide, the active metabolite of cyclophosphamide, can cross-link DNA and induce T cell apoptosis independently of caspase receptor activation. It also activates the mitochondrial death pathway through the production of reactive oxygen species (ROS).
-
GC42402
4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)
LY550408
4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine.
-
GC42405
4-hydroxy Atorvastatin (calcium salt)
p-hydroxy Atorvastatin, para-hydroxy Atorvastatin
4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
-
GC18425
4-hydroxy Atorvastatin lactone
p-hydroxy Atorvastatin lactone, para-hydroxy Atorvastatin lactone
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
-
GC42407
4-hydroxy Diclofenac
4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac.
-
GC42409
4-hydroxy Nebivolol (hydrochloride)
4-hydroxy Nebivolol is a major metabolite of nebivolol.
-
GC49575
4-hydroxy Omeprazole sulfide
4-hydroxy OMEP sulfide, 4-hydroxy OMP sulfide, 4-hydroxy OMZ sulfide
A metabolite of omeprazole
-
GC40879
4-hydroxy Solifenacin N-oxide
4-hydroxy Solifenacin N-oxide is an N-oxide form of 4-hydroxy solifenacin, the major metabolite of solifenacin .
-
GC42415
4-hydroxy Valsartan
CGP 71580, Valeryl 4-hydroxy Valsartan
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan.
-
GC18417
4-hydroxy Xylazine
p-hydroxy Xylazine, para-hydroxy Xylazine
4-hydroxy Xylazine is a metabolite of xylazine .
-
GC60517
4-Hydroxyatomoxetine
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine.
-
GC33522
4-Hydroxymephenytoin
4-Hydroxymephenytoin is the major metabolite of mephenytoin in the human body catalyzed by CYP2C19, an anti-epileptic drug and a typical substrate of CYP2C19.
-
GC18539
4-Hydroxyretinoic acid (4-HRA)
4-OH-atRA, 4-hydroxy RA
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring, primary metabolite derived from all-trans retinoic acid (ATRA) via cytochrome P450 enzyme metabolism.
-
GC39307
4-Methylamino antipyrine
4-Methylamino antipyrine is an active metabolite of Metamizole.
-
GC60523
4-Methylamino antipyrine hydrochloride
Metamizole Impurity C
An active metabolite of metamizole
-
GC49127
4-oxo Cyclophosphamide
4-keto CP, 4-keto Cyclophosphamide, NSC 139488, 4-oxo CP
An inactive metabolite of cyclophosphamide
-
GC41399
5α-dihydro Levonorgestrel
5α-DHLNG
5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel.
-
GC18582
5'-hydroxy Meloxicam
A metabolite of meloxicam
-
GC18542
5,6-dihydro-5-Fluorouracil
5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-Fluoro-5,6-dihydrouracil, 5-FUH2
5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).