GLPBio

Glutathione Peroxidase

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Glutathione Peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. Glutathione peroxidase functions to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Glutathione peroxidase plays a role in the development of celiac disease. Several isozymes glutathione peroxidase are encoded by different genes, which vary in cellular location and substrate specificity. Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in almost all the mammalian cells, though at much lower levels. Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans.

Products Related to Glutathione Peroxidase(48)

  • GC72788 structure
    GC72788HLF1-11
    CAS: 183623-03-2
    Purity: >99.00%

    HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent.

  • GC73066 structure
    GC73066GPX4-IN-2
    CAS: 2485005-22-7
    Purity: >98.00%

    GPX4-IN-2 is a potent GPX4 inhibitor.

  • GC73223 structure
    GC73223PROTAC GPX4 degrader-1
    CAS: 2916433-81-1
    Purity: >99.00%

    PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells.

  • GC73589 structure
    GC73589GPX4-IN-6
    CAS: 2922824-07-3
    Purity: >99.00%

    GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM.

  • GC78975 structure
    GC78975Myeloperoxidase, Human Neutrophil
    Purity: >98%

    Myeloperoxidase, Human Neutrophil is a peroxidase.

  • GC78976 structure
    GC78976NFE2L1 activator-1
    CAS: 3070514-51-8
    Purity: >98.50%

    NFE2L1 activator-1 (Compound 5b) is a potent nuclear factor erythroid 2-related factor 1 ( NFE2L1 ) activator ( EC 50 = 2.4 µM).

  • GC78977 structure
    GC78977GPX4-IN-1
    CAS: 2375356-92-4
    Purity: >99.50%

    GPX4-IN-1 is a potent GPX4 inhibitor.

  • GC78978 structure
    GC78978(rac)-Mitiperstat
    CAS: 1933460-18-4
    Purity: >98.00%

    (rac)-Mitiperstat ((rac)-AZD4831) is the racemic form of Mitiperstat.

  • GC81439 structure
    GC81439SZ0232
    CAS: 924851-91-2
    Purity: >99.00%

    SZ0232 is a selective mPGES-2 inhibitor.

  • GC81538 structure
    GC81538RSL3-NH2 hydrochloride
    CAS: 3051815-40-5
    Purity: >98.00%

    RSL3-NH2 hydrochloride is a GPX4 inhibitor and ferroptosis inducer.

  • GC81543 structure
    GC81543GPX4-IN-19
    CAS: 3102894-57-2
    Purity: >99.00%

    GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.

  • GC81546 structure
    GC81546iMQT_020
    CAS: 2463893-46-9
    Purity: >99.00%

    iMQT_020 is a selective allosteric SLC1A5_var inhibitor.

  • GC81634 structure
    GC816342-Acetamidophenol-d 3
    CAS: 122258-87-1
    Purity: >99.00%

    2-Acetamidophenol -d 3 (Orthocetamol-d 3 ) is the deuterium labeled 2-Acetamidophenol.

  • GC81638 structure
    GC81638PROTAC GPX4 degrader-5
    CAS: 3119292-91-7
    Purity: >95.00%

    PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader ( DC 50 = 28 nM).

  • GC81695 structure
    GC81695DIM-3,5-Cl2
    CAS: 2595179-74-9
    Purity: >99.00%

    DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively.

  • GC90714 structure
    GC90714LOC1886
    CAS: 951948-38-2
    Purity: >95.00%

    A GPX4 inhibitor

  • GC90827 structure
    GC90827GPX4 24
    Purity: >98.00%

    A GPX4 inhibitor

  • GC91083 structure
    GC91083Tiopronin-Cysteine Disulfide
    CAS: 77591-18-5
    Purity: >95.00%

    A metabolite of tiopronin

  • GC91091 structure
    GC91091Spirotetramat-d5
    CAS: 2469007-09-6
    Purity: >99.00%

    An internal standard for the quantification of spirotetramat

  • GC91157 structure
    GC91157C18
    CAS: 2922824-09-5
    Purity: >98.00%

    A covalent GPX4 inhibitor

  • GC91380 structure
    GC91380N6F11
    CAS: 851398-76-0
    Purity: >99.50%

    N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.

  • GC91623 structure
    GC91623Ferroptosis Inducer 24
    CAS: 28657-88-7
    Purity: >95.00%

    Ferroptosis inducer 24 is an inducer of ferroptosis.

  • GC92031 structure
    GC92031GPX4 Inhibitor 17
    Purity: >98.00%

    GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis.

  • GC92061 structure
    GC920611-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
    CAS: 161923-56-4
    Purity: >95.00%

    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC is an oxidized phospholipid that contains palmitic acid and 13(S)-HODE at the sn-1 and sn-2 positions, respectively.