GLPBio

PROTAC GPX4 degrader-1

Catalog No.: GC73223Purity:>99.00%
COASDSData Sheet
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells.

Products are for research use only. Not for human use. We do not sell to patients.

PROTAC GPX4 degrader-1
Cas No.: 2916433-81-1
1 mgIn Stock
$765.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells.

PROTAC GPX4 degrader-1 (DC-2) has been found to induce GPX4 degradation and subsequent ferroptosis[1].

References:
[1]. Han Wang, et al. Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells. Eur J Med Chem. 2023 Jun 5;254:115343.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2916433-81-1
Molecular Formula
C50H57ClN10O10
Molecular Weight
993.5
Solubility
DMSO : 100 mg/mL (100.65 mM; Need ultrasonic)
Storage
4°C, stored under nitrogen
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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